{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:29:24Z","timestamp":1791840564508,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Endoscopic local triamcinolone injection is a standard therapy for esophageal stricture (ES) prevention after extensive endoscopic submucosal dissection (ESD); however, oral prednisolone administration is a promising alternative. This trial aimed to investigate the superiority of oral prednisolone administration to local triamcinolone injection for ES prevention after extensive ESD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This phase 3, open\u2010label, multicenter, randomized controlled trial enrolled patients with extensive superficial esophageal squamous cell carcinoma. The primary endpoint was stricture\u2010free survival (SFS). Secondary endpoints were the number of endoscopic balloon dilations (EBDs) for 12\u2009weeks after ESD, dysphagia score \u2264\u20091 at 12\u2009weeks after ESD, and adverse events (AEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 281 patients from 45 institutions were enrolled. The 12\u2010week SFS rates were 88.5% (95% confidence interval [CI]: 81.6\u201392.9) and 94.8% (95% CI: 89.4\u201397.5) in the triamcinolone and prednisolone arms, respectively (hazard ratio 0.672, 90% CI [0.361\u20131.250],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.14). Thirty\u2010eight and 26 EBDs were performed for 14 and 10 patients, respectively, in the triamcinolone and prednisolone arms within 12\u2009weeks after ESD. In the triamcinolone and prednisolone arms, 73.8% (95% CI: 65.7\u201380.8) and 80.7% (95% CI: 73.2\u201386.9) of patients, respectively, had dysphagia scores \u2264\u20091 at 12\u2009weeks after ESD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.20). Grade 3\/4 AEs occurred in 12 (8.7%) and 9 patients (6.7%) in the triamcinolone and prednisolone arms, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While oral prednisolone administration and local triamcinolone injection demonstrated comparable outcomes, oral prednisolone did not demonstrate superiority for ES prevention after extensive esophageal ESD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.70195","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:07:32Z","timestamp":1781798852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Randomized Controlled Phase 3 Trial of Oral Prednisolone Administration Versus Local Triamcinolone Injection Therapy for Esophageal Stricture Prevention After Extensive Endoscopic Submucosal Dissection (\n                    <scp>JCOG1217<\/scp>\n                    )"],"prefix":"10.1111","volume":"38","author":[{"given":"Masaki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Division of Endoscopy Shimane Prefectural Central Hospital  Izumo Shimane Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Shizuoka Cancer Center  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Kanagawa Cancer Center  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"JCOG Data Center\/Operations Office National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sano","sequence":"additional","affiliation":[{"name":"JCOG Data Center\/Operations Office National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-6921","authenticated-orcid":false,"given":"Seiichiro","family":"Abe","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0408-3494","authenticated-orcid":false,"given":"Tomohiro","family":"Kadota","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Endoscopy National Cancer Center Hospital East  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ishikawa Prefectural Central Hospital  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hiroshima City North Medical Center Asa Citizens Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Fukuda","sequence":"additional","affiliation":[{"name":"JCOG Data Center\/Operations Office National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Endoscopy National Cancer Center Hospital East  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Gastrointestinal Endoscopy Study Group of the Japan Clinical Oncology Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1542\u20103565(05)00291\u20100"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.03.024"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.03.1114"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.02.040"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2003.73"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100029\u20101214867"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102050.2009.00954.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010012\u20102273\u20109"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.07.070"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101310107"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102005\u2010870531"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101326253"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.02.005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.09.011"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4065\/71.1.5"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388\u2010016\u20100551\u20107"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388\u2010023\u201000993\u20102"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.23.12.1060"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31824fff76"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101390770"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101390787"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.03.1484"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.06.025"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000526134"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102018\u20103911"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20100781\u20102333"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u2010118291"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388\u2010020\u201000730\u2010z"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010015\u20104719\u20103"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.08.022"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dox140"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443\u20101661.2011.01215.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/deo2.206"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.70195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/den.70195","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.70195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:53:15Z","timestamp":1784022795000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.70195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/den.70195"],"URL":"https:\/\/doi.org\/10.1111\/den.70195","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70195"}}