{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:53:04Z","timestamp":1792806784241,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Sarcopenia is a recognized risk factor in surgical oncology, yet its clinical significance in patients undergoing endoscopic resection (ER) remains controversial. This scoping review investigated the prevalence of sarcopenia and its association with technical outcomes, systemic complications, and long\u2010term prognosis in patients undergoing ER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We followed the PRISMA\u2010ScR framework and searched MEDLINE, Cochrane Central, Web of Science, and Ichushi Web up to November 12, 2025. Eligible studies involved patients undergoing ER (endoscopic submucosal dissection or endoscopic mucosal resection) for esophageal, gastric, or colorectal neoplasms, regardless of diagnostic criteria. A narrative synthesis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010eight studies, predominantly retrospective cohorts from East Asia, were included. Prevalence ranged from 13.9% to 72.7%. Most studies defined sarcopenia by skeletal muscle mass on computed tomography; only one prospective study incorporated muscle strength. Sarcopenia was generally not associated with technical outcomes such as en bloc resection or perforation. However, it was associated with systemic complications: post\u2010procedural pneumonia was more frequent in two of three studies (odds ratio 3.16 in one), moderate\u2010to\u2010severe adverse events (CTCAE \u2265\u20092) in three of four, and hospital stay was prolonged in all three reporting studies. Sarcopenia was also associated with poor overall survival (hazard ratios 1.7\u201315.0), driven by non\u2010disease\u2010specific mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sarcopenia does not compromise the technical safety of ER but is a critical marker for systemic complications and poor prognosis. Current evidence is limited by retrospective designs lacking muscle strength data. Future research should prioritize prospective assessment using multifaceted diagnostic criteria to refine risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.70210","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:09:59Z","timestamp":1781878199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Sarcopenia on Elderly Patients Undergoing Endoscopic Resection: Scoping Review"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6184-2215","authenticated-orcid":false,"given":"Hiroyuki","family":"Hisada","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Endoscopy and Endoscopic Surgery, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Next\u2010Generation Endoscopic Computer Vision, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Yakabi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Niimi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Endoscopy and Endoscopic Surgery, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-2099","authenticated-orcid":false,"given":"Naomi","family":"Kakushima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Endoscopy and Endoscopic Surgery, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutake","family":"Yamamichi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4074-1140","authenticated-orcid":false,"given":"Mitsuhiro","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  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of Additional Treatment, Comorbidities, and Nutritional Status on Skeletal Muscle Mass After ESD for Esophageal Cancer in Elderly Patients","volume":"120","author":"Matsuno K.","year":"2023","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010022\u201001923\u20102"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000536267"},{"key":"e_1_2_11_17_1","article-title":"Changes in Muscle Mass in Elderly Patients Undergoing Gastric ESD","volume":"120","author":"Inuyama M.","year":"2023","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013878"},{"key":"e_1_2_11_19_1","article-title":"Impact of Sarcopenia on the Multiplicity of Early Gastric Cancer in ESD Cases","volume":"116","author":"Kubota M.","year":"2019","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_11_20_1","article-title":"Prognosis of Elderly Patients With Non\u2010Curative Resection of Gastric ESD: Impact of Additional Surgery, Recurrence, and Sarcopenia","volume":"62","author":"Yamamoto Y.","year":"2020","journal-title":"Gastroenterological 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Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_11_30_1","first-page":"66","article-title":"Association Between Low Skeletal Muscle Mass and Prognosis in Elderly Patients With Early Gastric Cancer Undergoing Non\u2010Curative Endoscopic Resection","volume":"24","author":"Yamamoto Y.","year":"2022","journal-title":"Nihon Korei Shokakibyo Gakkai Shi"},{"key":"e_1_2_11_31_1","article-title":"Association Between Sarcopenia and the Selection of Additional Treatment for Non\u2010Curative Endoscopic Submucosal Dissection of Esophageal Cancer","volume":"65","author":"Nakao M.","year":"2023","journal-title":"Gastroenterological Endoscopy"},{"key":"e_1_2_11_32_1","article-title":"Association Between Prognosis and Sarcopenia After Endoscopic Submucosal Dissection for Gastric Cancer in Super\u2010Elderly Patients","volume":"65","author":"Shiraishi K.","year":"2023","journal-title":"Gastroenterological 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