{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:08:55Z","timestamp":1790690935739,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Endoscopic ultrasound\u2010guided radiofrequency ablation (EUS\u2010RFA) is increasingly used; however, clinical application remains unstandardized. We assessed real\u2010world practice among international users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional 70\u2010item survey was conducted. Results are presented descriptively (numbers, percentages).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 91 of 175 invited physicians from Europe (74.4%), North America (13.3%), and Asia (12.2%) completed the survey. EUS\u2010RFA was performed by 94.1% of respondents for insulinoma, with heterogeneous responses for other indications. Most physicians (96.3%) performed EUS\u2010RFA under deep sedation or general anesthesia; marked variability was reported on antibiotic prophylaxis (57.5%), aggressive hydration (52.5%), generator power settings, ablation strategy, or probe selection. Lesions involving or located \u2264\u20091\u2009mm from the main pancreatic duct were considered high risk by 97.5% and 85.0%, respectively, yet no standardized preventive strategy was identified. Post\u2010procedural management and follow\u2010up were heterogeneous, with a high proportion of responses for definitions of technical success (88.8%), clinical success in insulinoma (92.3%), and disease recurrence (97.5%), with high variability for definitions of partial ablation and post\u2010RFA pancreatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite the global expansion of EUS\u2010RFA, clinical practice remains highly heterogeneous and geographically skewed. The lack of standardized methodology and terminology poses significant barriers to generating high\u2010quality evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.70212","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T07:47:07Z","timestamp":1782719227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Methodology Assessment of Endoscopic Ultrasound Radiofrequency Ablation (\n                    <scp>EUS<\/scp>\n                    \u2010\n                    <scp>RFA<\/scp>\n                    ) for Pancreatic Neoplasms: Results From an International Survey"],"prefix":"10.1111","volume":"38","author":[{"given":"Andrea","family":"Lisotti","sequence":"first","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Imola Hospital, AUSL Imola, and Department of Medical and Surgical Sciences (DIMEC) University of Bologna  Bologna Italy"},{"name":"Department of Gastroenterology and Digestive Endoscopy H\u00f4pital Priv\u00e9 Jean Mermoz, Ramsay Sant\u00e9  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Tacelli","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Endoscopy and Endosonography Division IRCCS San Raffaele Hospital, Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano Francesco","family":"Crin\u00f2","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Masciangelo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Imola Hospital, AUSL Imola, and Department of Medical and Surgical Sciences (DIMEC) University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Fusaroli","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Imola Hospital, AUSL Imola, and Department of Medical and Surgical Sciences (DIMEC) University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Barthet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Digestive Endoscopy H\u00f4pital Nord, Assistance Publique\u2013H\u00f4pitaux de Marseille, Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirav","family":"Thosani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition McGovern Medical School at UTHealth  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Conti Bellocchi","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Leblanc","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Digestive Endoscopy H\u00f4pital Priv\u00e9 Jean Mermoz, Ramsay Sant\u00e9  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-8625","authenticated-orcid":false,"given":"Tawfik","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Digestive Endoscopy H\u00f4pital Priv\u00e9 Jean Mermoz, Ramsay Sant\u00e9  Lyon France"},{"name":"Department of Gastroenterology Galilee Medical Center  Nahariya Israel"},{"name":"Faculty of Medicine in the Galilee Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Giorgio","family":"Arcidiacono","sequence":"additional","affiliation":[{"name":"Pancreatobiliary Endoscopy and Endosonography Division IRCCS San Raffaele Hospital, Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-2156","authenticated-orcid":false,"given":"Antonio","family":"Facciorusso","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Experimental Medicine University of Salento  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Caillol","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Digestive Endoscopy Institut Paoli\u2010Calmettes, Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Giovannini","sequence":"additional","affiliation":[{"name":"Department of Endoscopy and Endoscopic Ultrasound Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Fuccio","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna; University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanta","family":"Samanta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony Y. B.","family":"Teoh","sequence":"additional","affiliation":[{"name":"Department of Surgery Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Endoscopy Center Hong Kong Sanatorium and Hospital  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-6568","authenticated-orcid":false,"given":"Takeshi","family":"Ogura","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roald Flesland","family":"Havre","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somashekar G.","family":"Krishna","sequence":"additional","affiliation":[{"name":"Division of 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