{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:19:30Z","timestamp":1787638770570,"version":"build-2736575974"},"reference-count":71,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Image\u2010enhanced endoscopy (IEE) technologies have been developed to improve colorectal polyp detection, but their comparative efficacy remains uncertain. We performed a network meta\u2010analysis to compare the efficacy of major IEE modalities on colorectal polyp detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched MEDLINE, Embase, and CENTRAL for randomized controlled trials comparing seven IEE modalities (autofluorescence imaging, blue\u2010light imaging, flexible spectral imaging color enhancement, i\u2010scan, linked color imaging [LCI], narrow band imaging [NBI], and texture and color enhancement imaging [TXI]) with white\u2010light imaging (WLI). The primary outcome was the comparison of performance of IEE systems in adenoma detection rate (ADR); the secondary outcome was sessile serrated lesion detection rate (SSLDR). We estimated the number needed to screen (NNS) with 95% credible intervals (CrIs). Study credibility was assessed using the Confidence in Network Meta\u2010analysis (CINeMA) framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010three randomized controlled trials encompassing 34,364 patients were included. Compared with WLI, moderate\u2010confidence evidence supported improvements in ADR with TXI (NNS 13, 95% CrIs 7\u201332), LCI (NNS 17, 95% CrIs 11\u201331), and NBI (NNS 35, 95% CrIs 18\u2013139), whereas low\u2010confidence evidence supported benefits for i\u2010scan (NNS 7, 95% CrIs 3\u201318). Direct comparison across IEEs demonstrated little\u2010to\u2010no clinically meaningful differences in ADR. For SSLDR, moderate\u2010confidence evidence supported improvements with LCI (NNS 29, 95% CrIs 15\u201396) and NBI (NNS 38, 95% CrIs 19\u2013143) compared with WLI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LCI demonstrated the most robust and reproducible performance across multiple analyses with moderate\u2010confidence evidence, although differences among IEE modalities were generally modest.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.70262","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:06:31Z","timestamp":1787011591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Performance of Image\u2010Enhanced Endoscopy for Adenoma and Sessile Serrated Lesion Detection: A Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"38","author":[{"given":"Satoshi","family":"Shinozaki","sequence":"first","affiliation":[{"name":"Shinozaki Medical Clinic  Utsunomiya Japan"},{"name":"Division of Gastroenterology, Department of Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological, General and Transplant Surgery, Department of Surgery Jichi Medical University  Shimotsuke Japan"},{"name":"Division of Community and Family Medicine Jichi Medical University  Shimotsuke\u2010City Japan"},{"name":"Division of Gastroenterology and Farncombe Family Digestive Health Research Institute, Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Yano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1309086"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.429"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.07.021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.03.026"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13613"},{"key":"e_1_2_10_7_1","article-title":"Linked Color Imaging Versus Conventional White\u2010Light Colonoscopy for the Detection of Colorectal Polyps","volume":"8","author":"Watanabe J.","year":"2025","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099682"},{"key":"e_1_2_10_12_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J. 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