{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:59:13Z","timestamp":1790305153912,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Endoscopic papillectomy (EP) is a minimally invasive treatment for ampullary tumors; however, its safety in elderly patients remains unclear. We aimed to evaluate the feasibility and clinical outcomes of EP in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective study included 255 patients with ampullary tumors who underwent EP between April 2008 and September 2025 at three collaborating institutions. Patients aged \u2265\u200975\u2009years were defined as elderly; complication rates and clinical outcomes were compared with the non\u2010elderly group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The elderly group had a significantly higher Charlson Comorbidity Index (1.0 [0\u20138] vs. 0 [0\u20137];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). The elderly group demonstrated significantly lower rates of overall complications (29.0% vs. 48.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), delayed bleeding (4.3% vs. 23.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and pancreatitis (11.6% vs. 23.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041) than the non\u2010elderly group. Serious complications rate (4.3% vs. 4.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.000), median hospital stay (12 [7\u201373] vs. 13 [4\u201340] days;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.408) were comparable between groups. Multivariate analysis showed that age\u2009\u2265\u200975\u2009years was independently associated with a reduced risk of delayed bleeding (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002; odds ratio [OR], 0.14) and pancreatitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029; OR, 0.39).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EP in patients aged \u2265\u200975\u2009years was associated with lower complication rates and may be a feasible treatment option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.70284","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:07:51Z","timestamp":1789031271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic Papillectomy May Be a Feasible Treatment Option for Elderly Patients With Ampullary Tumors: A\u00a0Multicenter Retrospective Study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3154-5535","authenticated-orcid":false,"given":"Noriki","family":"Kasuga","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Yokohama Rosai Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2482-6707","authenticated-orcid":false,"given":"Yusuke","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University Hospital  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