{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:51:01Z","timestamp":1791255061241,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26K15700"],"award-info":[{"award-number":["26K15700"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Endoscopic ultrasound shear wave elastography (EUS\u2010SWE) enables quantitative, noninvasive assessment of tissue elasticity. However, the association between EUS\u2010SWE and pancreatic histology remains unclear. This study aimed to investigate the utility of EUS\u2010SWE for predicting pancreatic fibrosis by comparing it with histological findings of resected specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent EUS\u2010SWE before pancreatectomy between October 2019 and October 2024 were retrospectively enrolled. SWE was performed near the surgical resection margin, and shear wave velocity (Vs, m\/s) was measured. The number of EUS morphological findings according to the Rosemont classification was obtained. Histological findings were assessed using quantitative analysis and grading analysis. The association between EUS\u2010SWE or the number of EUS morphological findings and histological findings, as well as the diagnostic performance of EUS\u2010SWE and EUS morphological findings for predicting histological fibrosis at predefined fibrosis thresholds (\u2265\u20095%, \u2265\u200910%, \u2265\u200915%, and \u2265\u200920%) was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010four patients were included. Vs correlated significantly with quantitative fibrosis (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.73,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), but not with fatty infiltration and inflammation. The number of EUS morphological findings correlated only with fibrosis grade (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041). EUS\u2010SWE had higher diagnostic accuracy than EUS morphological findings for predicting histological fibrosis at all thresholds (91.2%, 88.2%, 82.4%, and 88.2% vs. 55.9%, 67.6%, 55.9%, and 50.0%, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EUS\u2010SWE may serve as a quantitative, noninvasive method for evaluating pancreatic fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>UMIN ID: 000058397<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.70308","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:05:26Z","timestamp":1791252326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>EUS<\/scp>\n                    Shear Wave Elastography for Assessing Pancreatic Fibrosis: An Exploratory Study of Its Histological Correlation"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1812-2726","authenticated-orcid":false,"given":"Akiya","family":"Nakahata","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-5708","authenticated-orcid":false,"given":"Yasunobu","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9478-9692","authenticated-orcid":false,"given":"Fumiyoshi","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokazu","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8086-7841","authenticated-orcid":false,"given":"Hiromu","family":"Morishita","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Shishimoto","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kawaji","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-2509","authenticated-orcid":false,"given":"Takashi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Wakayama Medical University  Wakayama 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