{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:32:03Z","timestamp":1791275523258,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Advanced Multimodal Neuroimaging Training Program","award":["T90DA022759\/R90DA023427"],"award-info":[{"award-number":["T90DA022759\/R90DA023427"]}]},{"name":"Laboratories of Cognitive Neuroscience at Boston Children's Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Science"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Humans are born with the ability to mentally represent the approximate numerosity of a set of objects, but little is known about the brain systems that sub\u2010serve this ability early in life and their relation to the brain systems underlying symbolic number and mathematics later in development. Here we investigate processing of numerical magnitudes before the acquisition of a symbolic numerical system or even spoken language, by measuring the brain response to numerosity changes in pre\u2010verbal infants using functional near\u2010infrared spectroscopy (<jats:styled-content style=\"fixed-case\">fNIRS<\/jats:styled-content>). To do this, we presented infants with two types of numerical stimulus blocks: number change blocks that presented dot arrays alternating in numerosity and no change blocks that presented dot arrays all with the same number. Images were carefully constructed to rule out the possibility that responses to number changes could be due to non\u2010numerical stimulus properties that tend to co\u2010vary with number. Interleaved with the two types of numerical blocks were audio\u2010visual animations designed to increase attention. We observed that number change blocks evoked an increase in oxygenated hemoglobin over a focal right parietal region that was greater than that observed during no change blocks and during audio\u2010visual attention blocks. The location of this effect was consistent with intra\u2010parietal activity seen in older children and adults for both symbolic and non\u2010symbolic numerical tasks. A distinct set of bilateral occipital and middle parietal channels responded more to the attention\u2010grabbing animations than to either of the types of numerical stimuli, further dissociating the specific right parietal response to number from a more general bilateral visual or attentional response. These results provide the strongest evidence to date that the right parietal cortex is specialized for numerical processing in infancy, as the response to number is dissociated from visual change processing and general attentional processing.<\/jats:p>","DOI":"10.1111\/desc.12333","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T03:26:49Z","timestamp":1442978809000},"page":"757-769","source":"Crossref","is-referenced-by-count":48,"title":["Functional brain organization for number processing in pre\u2010verbal infants"],"prefix":"10.1111","volume":"19","author":[{"given":"Laura A.","family":"Edwards","sequence":"first","affiliation":[{"name":"Graduate School of Education Harvard University USA"},{"name":"Boston Children's Hospital Harvard Medical School USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer B.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Psychology College of Staten Island City University of New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charline E.","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Illinois Urbana\u2010Champaign USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Hyde","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Illinois Urbana\u2010Champaign USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.11.1820"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lindif.2011.07.013"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"7","article-title":"Questioning the questions that have been asked about the infant brain using NIRS","volume":"29","author":"Aslin R.N.","year":"2013","journal-title":"Cognitive Neuropsychology"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2012.04.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.750253"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040125"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-006-0820-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195367638.001.0001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/9609.001.0001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00147"},{"key":"e_1_2_8_12_1","volume-title":"The number sense","author":"Dehaene S.","year":"1997"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/02643290244000239"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407789102"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2007.08.011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12215"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.05.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.02.006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2010.07.004"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.48.00D280"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.030"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2010.00987.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21352"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060011"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812142106"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.03.050"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0046737"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2006.10.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2009.00948.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0032986"},{"key":"e_1_2_8_31_1","volume-title":"An introduction to the event\u2010related potential technique","author":"Luck S.J.","year":"2005"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.03.024"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135550"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0657"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.08.026"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.10.014"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.11.022"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0913"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00107-2"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2936-12.2013"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2009.0960"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2010.11.012"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-210X.2010.00014.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/31\/5\/004"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302751110"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01550-0"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00021-1"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.13.7836"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.049"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2004.08.005"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a007090"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.1852551"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.064"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0285(92)90008-P"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-0277(99)00066-9"}],"container-title":["Developmental Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdesc.12333","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/desc.12333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:07:04Z","timestamp":1696302424000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/desc.12333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,22]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/desc.12333"],"URL":"https:\/\/doi.org\/10.1111\/desc.12333","archive":["Portico"],"relation":{},"ISSN":["1363-755X","1467-7687"],"issn-type":[{"value":"1363-755X","type":"print"},{"value":"1467-7687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,22]]}}}