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In the present <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> study we explored the activation of areas belonging to the <jats:styled-content style=\"fixed-case\">AON<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content> in children and adults during observation of complex hand\u2010grasping actions, as compared to observation of simple grasping acts executed with the left and the right hand, seen from a first person perspective. The results indicate that during the action observation tasks in children there was activation of a cortical network similar to that found in adults, including the premotor cortex, the posterior part of the inferior frontal gyrus and the posterior parietal lobe. However, the activation in children was more widespread and showed a higher inter\u2010subject variability compared with adults. Furthermore, the activated network seems more lateralized to the left hemisphere in adults and more bilateral in children, with a linear growth of lateralization index as a function of age. Finally, in children the activation in the anterior intraparietal cortex (<jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content>) of each hemisphere was higher during observation of the contralateral hand (hand identity effect) and during the observation of complex actions relative to simple grasping acts, confirming the role of <jats:styled-content style=\"fixed-case\">AIP<\/jats:styled-content> for action\u2010related hand identity previously described in adults. These results support the assumption that structure and size of action representations are sensitive to mechanisms of development and show physiological plasticity. These properties of the <jats:styled-content style=\"fixed-case\">AON<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MNS<\/jats:styled-content> could constitute a powerful tool for spontaneous reorganization and recovery of motor deficits after brain injury in children and in adults, as well as for specific rehabilitation programmes.<\/jats:p>","DOI":"10.1111\/desc.12353","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T05:57:06Z","timestamp":1446703026000},"page":"1075-1086","source":"Crossref","is-referenced-by-count":39,"title":["Action observation network in childhood: a comparative <scp>fMRI<\/scp> study with adults"],"prefix":"10.1111","volume":"19","author":[{"given":"Laura","family":"Biagi","sequence":"first","affiliation":[{"name":"Department of Developmental Neuroscience and MR Unit IRCCS Fondazione Stella Maris Calambrone 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