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Yet little is known about the intrinsic functional brain organization that contributes to poor math skills in affected children. It is now increasingly recognized that math cognition requires coordinated interaction within a large\u2010scale fronto\u2010parietal network anchored in the intraparietal sulcus (\n IPS<\/jats:styled-content>\n ). Here we characterize intrinsic functional connectivity within this\n IPS<\/jats:styled-content>\n \u2010network in children with\n MD<\/jats:styled-content>\n , relative to a group of typically developing (\n TD<\/jats:styled-content>\n ) children who were matched on age, gender,\n IQ<\/jats:styled-content>\n , working memory, and reading abilities. Compared to\n TD<\/jats:styled-content>\n children, children with\n MD<\/jats:styled-content>\n showed hyper\u2010connectivity of the\n IPS<\/jats:styled-content>\n with a bilateral fronto\u2010parietal network. Importantly, aberrant\n IPS<\/jats:styled-content>\n connectivity patterns accurately discriminated children with\n MD<\/jats:styled-content>\n and\n TD<\/jats:styled-content>\n children, highlighting the possibility for using\n IPS<\/jats:styled-content>\n connectivity as a brain\u2010based biomarker of\n MD<\/jats:styled-content>\n . To further investigate regional abnormalities contributing to network\u2010level deficits in children with\n MD<\/jats:styled-content>\n , we performed whole\u2010brain analyses of intrinsic low\u2010frequency fluctuations. Notably, children with\n MD<\/jats:styled-content>\n showed higher low\u2010frequency fluctuations in multiple fronto\u2010parietal areas that overlapped with brain regions that exhibited hyper\u2010connectivity with the\n IPS<\/jats:styled-content>\n . Taken together, our findings suggest that\n MD<\/jats:styled-content>\n in children is characterized by robust network\u2010level aberrations, and is not an isolated dysfunction of the\n IPS<\/jats:styled-content>\n . We hypothesize that intrinsic hyper\u2010connectivity and enhanced low\u2010frequency fluctuations may limit flexible resource allocation, and contribute to aberrant recruitment of task\u2010related brain regions during numerical problem solving in children with\n MD<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/desc.12399","type":"journal-article","created":{"date-parts":[[2016,2,14]],"date-time":"2016-02-14T19:05:59Z","timestamp":1455476759000},"page":"613-631","source":"Crossref","is-referenced-by-count":85,"title":["Parietal hyper\u2010connectivity, aberrant brain organization, and circuit\u2010based biomarkers in children with mathematical disabilities"],"prefix":"10.1111","volume":"19","author":[{"given":"Dietsje","family":"Jolles","sequence":"first","affiliation":[{"name":"Department of Psychiatry & Behavioral Sciences Stanford University School of Medicine USA"},{"name":"Education and Child Studies Leiden University The 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