{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:00Z","timestamp":1787014080163,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH090062"],"award-info":[{"award-number":["R01MH090062"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Science"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>\n \n Verbal\u2013spatial discrepancies are common in healthy individuals and in those with neurodevelopmental disorders associated with cognitive control deficits including: Autism Spectrum Disorder, Non\u2010Verbal Learning Disability, Fragile X, 22q11 deletion, and Turner Syndrome. Previous data from healthy individuals suggest that the magnitude of the difference between verbal\n IQ<\/jats:styled-content>\n (\n VIQ<\/jats:styled-content>\n ) and performance\n IQ<\/jats:styled-content>\n (\n PIQ<\/jats:styled-content>\n ) scores (the\n VIQ<\/jats:styled-content>\n >\n PIQ<\/jats:styled-content>\n discrepancy) is associated with reduced thickness in frontal and parietal cortices (inferior frontal, anterior cingulate, inferior parietal lobule, and supramarginal gyrus) that support cognitive control. Unknown is whether the\n VIQ<\/jats:styled-content>\n >\n PIQ<\/jats:styled-content>\n discrepancy is associated with functional deficits in these areas in healthy or ill children and adolescents. We assessed the effects of the\n VIQ<\/jats:styled-content>\n >\n PIQ<\/jats:styled-content>\n discrepancy on\n fMRI BOLD<\/jats:styled-content>\n response during the resolution of cognitive conflict in 55 healthy children and adolescents during performance of a Simon Spatial Incompatibility task. As the magnitude of the\n VIQ<\/jats:styled-content>\n >\n PIQ<\/jats:styled-content>\n discrepancy increased, activation of fronto\u2010striatal, limbic, and temporal regions decreased during conflict resolution (\n p\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n .05, corrected). In exploratory analyses, the\n VIQ<\/jats:styled-content>\n >\n PIQ<\/jats:styled-content>\n discrepancy was associated with reduced functional connectivity from right inferior frontal gyrus to right thalamus and increased functional connectivity to right supramarginal gyrus (\n p<\/jats:italic>\n s\u00a0<\u00a0.03, uncorrected). The\n VIQ<\/jats:styled-content>\n >\n PIQ<\/jats:styled-content>\n discrepancy may be an important aspect of an individual's cognitive profile and likely contributes to, or is associated with, deficient cognitive control processes characteristic of many childhood disorders.\n <\/jats:p>","DOI":"10.1111\/desc.12550","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T02:16:38Z","timestamp":1487124998000},"source":"Crossref","is-referenced-by-count":16,"title":["Verbal\u2013spatial\n IQ<\/scp>\n discrepancies impact brain activation associated with the resolution of cognitive conflict in children and adolescents"],"prefix":"10.1111","volume":"21","author":[{"given":"Amy E.","family":"Margolis","sequence":"first","affiliation":[{"name":"The Division of Child and Adolescent Psychiatry in the Department of Psychiatry the New York State Psychiatric Institute and the College of Physicians & Surgeons Columbia University New York 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishun","family":"Wang","sequence":"additional","affiliation":[{"name":"The Division of Child and Adolescent Psychiatry in the Department of Psychiatry the New York State Psychiatric Institute and the College of Physicians & Surgeons Columbia University New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Marsh","sequence":"additional","affiliation":[{"name":"The Division of Child and Adolescent Psychiatry in the Department of Psychiatry the New York State Psychiatric Institute and the College of Physicians & Surgeons Columbia University New York 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