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Remarkably, children and adults with developmental absence of the corpus callosum (callosal dysgenesis, CD) show typical interhemispheric integration, which is classically impaired in adult split\u2010brain patients, for whom the corpus callosum is surgically severed. Tovar\u2010Moll and colleagues (2014) proposed alternative neural pathways involved in the preservation of interhemispheric transfer. In a sample of six adults with CD, they revealed two homotopic bundles crossing the midline via the anterior and posterior commissures and connecting parietal cortices, and the microstructural properties of these aberrant bundles were associated with functional connectivity of these regions. The aberrant bundles were specific to CD and not visualised in healthy brains. We extended this study in a developmental cohort of 20 children with CD and 29 typically developing controls (TDC). The two anomalous white\u2010matter bundles were visualised using tractography. Associations between structural properties of these bundles and their regional functional connectivity were explored. The proposed atypical bundles were observed in 30% of our CD cohort crossing via the anterior commissure, and in 30% crossing via the posterior commissure (also observed in 6.9% of TDC). However, the structural property measures of these bundles were not associated with parietal functional connectivity, bringing into question their role and implication for interhemispheric functional connectivity in CD. It is possible that very early disruption of embryological callosal development enhances neuroplasticity and facilitates the formation of these proposed alternative neural pathways, but further evidence is needed.<\/jats:p>","DOI":"10.1111\/desc.13126","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T21:00:42Z","timestamp":1622581242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Revisiting brain rewiring and plasticity in children born without corpus callosum"],"prefix":"10.1111","volume":"24","author":[{"given":"Vanessa","family":"Siffredi","sequence":"first","affiliation":[{"name":"Medical Image Processing Lab, Institute of Bioengineering, Center for Neuroprosthetics Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne  Lausanne, VD Switzerland"},{"name":"Department of Radiology and Medical Informatics, Faculty of Medicine University of Geneva, Geneva  Geneva Switzerland"},{"name":"Brain and Mind Research, Clinical Sciences Murdoch Children's Research Institute  Melbourne Australia"},{"name":"Division of Development and Growth, Department of Paediatrics, Faculty of Medicine University of Geneva, Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria G.","family":"Preti","sequence":"additional","affiliation":[{"name":"Medical Image Processing Lab, Institute of Bioengineering, Center for Neuroprosthetics Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne  Lausanne, VD Switzerland"},{"name":"Department of Radiology and Medical Informatics, Faculty of Medicine University of Geneva, Geneva  Geneva Switzerland"},{"name":"CIBM Center for Biomedical Imaging  Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Obertino","sequence":"additional","affiliation":[{"name":"Medical Image Processing Lab, Institute of Bioengineering, Center for Neuroprosthetics Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne  Lausanne, VD Switzerland"},{"name":"Department of Radiology and Medical Informatics, Faculty of Medicine University of Geneva, Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Leventer","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Melbourne  Melbourne Australia"},{"name":"Department of Neurology Royal Children's Hospital  Melbourne Australia"},{"name":"Neuroscience Research, Clinical Sciences Murdoch Children's Research Institute  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda G.","family":"Wood","sequence":"additional","affiliation":[{"name":"Brain and Mind Research, Clinical Sciences Murdoch Children's Research Institute  Melbourne Australia"},{"name":"School of Life and Health Sciences &amp; 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