{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:45:02Z","timestamp":1791557102567,"version":"4.3.4"},"reference-count":73,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Science"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reading disorders are common in children and can impact academic success, mental health, and career prospects. Reading is supported by network of interconnected left hemisphere brain regions, including temporo\u2010parietal, occipito\u2010temporal, and inferior\u2010frontal circuits. Poor readers often show hypoactivation and reduced gray matter volumes in this reading network, with hyperactivation and increased volumes in the posterior right hemisphere. We assessed gray matter development longitudinally in pre\u2010reading children aged 2\u20135 years using magnetic resonance imaging (MRI) (<jats:italic>N<\/jats:italic>\u00a0=\u00a032, 110 MRI scans; mean age: 4.40 \u00b1 0.77 years), half of whom had a family history of reading disorder. The family history group showed slower proportional growth (relative to total brain volume) in the left supramarginal and inferior frontal gyri, and faster proportional growth in the right angular, right fusiform, and bilateral lingual gyri. This suggests delayed development of left hemisphere reading areas in children with a family history of dyslexia, along with faster growth in right homologues. This alternate development pattern may predispose the brain to later reading difficulties and may later manifest as the commonly noted compensatory mechanisms. The results of this study further shows our understanding of structural brain alterations that may form the neurological basis of reading difficulties.<\/jats:p>","DOI":"10.1111\/desc.13160","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T06:51:30Z","timestamp":1626677490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Altered gray matter development in pre\u2010reading children with a family history of reading disorder"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-6513","authenticated-orcid":false,"given":"Curtis","family":"Ostertag","sequence":"first","affiliation":[{"name":"Department of Radiology University of Calgary  Calgary AB Canada"},{"name":"Owerko Centre Alberta Children Hospital Research Institute University of Calgary  Calgary AB Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-6645","authenticated-orcid":false,"given":"Jess E.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Calgary  Calgary AB Canada"},{"name":"Owerko Centre Alberta Children Hospital Research Institute University of Calgary  Calgary AB Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1323-5832","authenticated-orcid":false,"given":"Deborah","family":"Dewey","sequence":"additional","affiliation":[{"name":"Owerko Centre Alberta Children Hospital Research Institute University of Calgary  Calgary AB Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary AB Canada"},{"name":"Department of Pediatrics University of Calgary  Calgary AB Canada"},{"name":"Department of Community Health Sciences University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5733-2127","authenticated-orcid":false,"given":"Bennett","family":"Landman","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2096-8065","authenticated-orcid":false,"given":"Yuankai","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0344-4032","authenticated-orcid":false,"given":"Catherine","family":"Lebel","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Calgary  Calgary AB Canada"},{"name":"Owerko Centre Alberta Children Hospital Research Institute University of Calgary  Calgary AB Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2014.06.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2019.09.010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116903"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.024"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/lnc3.12252"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12153"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2004.00252.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11881-016-0138-y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101715"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu229"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.2.291"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-016-9656-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1044\/2018_LSHSS-DYSLC-18-0020"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.05.008"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.04.058"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70268-5"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1772"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2012.09.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/002221940103400606"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000411"},{"key":"e_1_2_10_23_1","first-page":"10574","article-title":"Improved stability of whole brain surface parcellation with multi\u2010atlas segmentation","author":"Huo Y.","year":"2018","journal-title":"Proceedings of Spie the International Society for Optical Engineering"},{"key":"e_1_2_10_24_1","first-page":"9784","article-title":"Combining multi\u2010atlas segmentation with brain surface estimation","author":"Huo Y.","year":"2016","journal-title":"Proceedings of Spie the International Society for Optical Engineering"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.05.030"},{"key":"e_1_2_10_26_1","volume-title":"IBM SPSS Statistics for Macintosh","author":"IBM","year":"2017"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8709.2012.00433.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00278"},{"issue":"4","key":"e_1_2_10_29_1","first-page":"265","article-title":"Brain plasticity and behaviour in the developing brain","volume":"20","author":"Kolb B.","year":"2011","journal-title":"Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent"},{"key":"e_1_2_10_30_1","volume-title":"Nepsy\u2010ii","author":"Korkman M.","year":"2007"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20425"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2019.100633"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043122"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.36.5.596"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22749"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2019.0728"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/brln.2000.2287"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2014.09.007"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.01.007"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcs.1383"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.08.018"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032814-112842"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9924(01)00060-0"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.055"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht104"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107721109"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.04.010"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2019.100682"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2020.105224"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00120"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.040"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22127"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4383-12.2013"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.046516"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858412440596"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15326942dn3001_5"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21093"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579408000631"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2012.00161"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9450.2008.00688.x"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20177"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00146"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.01.060"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw348"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2016.06.007"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2015.05.006"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022219411402692"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci3031060"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2017.10.008"},{"key":"e_1_2_10_70_1","volume-title":"Wechsler preschool and primary scale of intelligence","author":"Wechsler D.","year":"2012"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/lnc3.12239"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165802"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1109\/MPUL.2017.2701493"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2015.12.004"}],"container-title":["Developmental Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/desc.13160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/desc.13160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/desc.13160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T13:03:19Z","timestamp":1693141399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/desc.13160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,26]]},"references-count":73,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/desc.13160"],"URL":"https:\/\/doi.org\/10.1111\/desc.13160","archive":["Portico"],"relation":{},"ISSN":["1363-755X","1467-7687"],"issn-type":[{"value":"1363-755X","type":"print"},{"value":"1467-7687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,26]]},"assertion":[{"value":"2021-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13160"}}