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Therefore, phonologically\u2010based interventions may not be most helpful in Chinese. In this study, we compared a phonological and a morphological intervention (MI) in Chinese children with RD both behaviorally and neurologically. We recruited 80 fifth\u2010grade Chinese children, including 18 typically developing children as age controls (AC), and 62 children with RD, 22 of whom received the phonological intervention (PI), 22 of whom received the MI, and 18 served as waiting\u2010list controls (WL). An auditory rhyming task and a visual spelling task were employed to examine brain activation before and after the intervention. We found that the PI and MI both effectively improved character naming, sentence reading fluency, one\u2010minute irregular character reading and phonological awareness compared with the WL group. At the brain level, the PI group showed greater increase of brain activation in the right middle temporal gyrus than the MI and WL following the intervention in an auditory rhyming task, suggesting compensatory phonological strategies developed in PI. The MI group showed greater increase of brain activation in the left middle frontal gyrus, left inferior frontal gyrus and left fusiform gyrus than the PI and the WL group following the intervention in a visual spelling task, suggesting functional normalization, because these regions were less activated in children with RD than typical controls before the intervention. These findings suggest intervention\u2010specific brain changes with otherwise similar effectiveness in the behavior. It provides important insights in understanding brain mechanisms underlying behavioral intervention in children with RD.<\/jats:p><jats:p><jats:bold>Trial Registration<\/jats:bold>: This study's design was preregistered at the Chinese Clinical Trial Registry (ChiCTR2300067536), see [<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.chictr.org.cn\">https:\/\/www.chictr.org.cn<\/jats:ext-link>]<\/jats:p>","DOI":"10.1111\/desc.70038","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T09:30:24Z","timestamp":1749375024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brain Changes Following Two Reading Interventions in Chinese Children With Reading Disability"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7086-3520","authenticated-orcid":false,"given":"Guoyan","family":"Feng","sequence":"first","affiliation":[{"name":"School of Public Administration Guangzhou City Polytechnic  Guangzhou China"},{"name":"Department of Psychology Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linling","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Special education The University of Texas at Austin  Austin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Shi","sequence":"additional","affiliation":[{"name":"Experimental Research Center of Medical and Psychological Science (ERC\u2010MPS) School of Psychology, Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2801-3335","authenticated-orcid":false,"given":"Xiaohui","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Psychology The University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqiong","family":"Liang","sequence":"additional","affiliation":[{"name":"Baini Town Central Primary School  Foshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xianlie Middle Road Primary School  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyi","family":"Zuo","sequence":"additional","affiliation":[{"name":"Taiping Primary School  Foshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-6038","authenticated-orcid":false,"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychology The University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Psychology The University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.06.009"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313830050154485"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.062"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165\u20100173(03)00172\u20103"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083668"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21384"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2009.21065"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"1","article-title":"Semantics of the Visual Environment Encoded in Parahippocampal Cortex","volume":"28","author":"Bonner M. 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