{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:08:46Z","timestamp":1790172526312,"version":"4.1.0"},"reference-count":111,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Developmental dyslexia (DD) is a prevalent neurodevelopmental disorder that significantly affects academic learning and social development. Although numerous brain regions have been implicated in DD under both task\u2010based and resting\u2010state conditions, dysfunctions in large\u2010scale functional coordination across brain systems in DD remains poorly understood. Using AES\u2010SDM, we conducted a meta\u2010analysis of seed\u2010based whole\u2010brain functional connectivity (FC) studies, including 12 task\u2010based studies with 226 dyslexics and 232 age\u2010matched controls, and 7 resting\u2010state studies with 120 dyslexics and 145 controls. Results revealed consistently reduced FC between the left inferior frontal gyrus (IFG) and the left fusiform gyrus (FFG) in dyslexics compared with age\u2010matched controls across both task and resting states, suggesting a core neural pathway underlying DD. In addition, task\u2010specific abnormalities were identified, including hypoconnectivity between the left IFG and the right cerebellum, and hyperconnectivity between the left IFG and the bilateral angular gyrus (AG), anterior cingulate cortex (ACC), and left thalamus. By contrast, resting\u2010state analyses identified additional hypoconnectivity between the left FFG and the posterior cingulate cortex (PCC). Together, these findings suggest that DD is associated with widespread disruption in functional integration across the brain, shedding new light on its neural mechanisms of DD and pointing to potential connectivity\u2010based biomarkers for diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Dyslexics exhibited consistent hypoconnectivity between the left inferior frontal gyrus and the left fusiform gyrus across both task and resting conditions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Under the task condition, dyslexics showed specific hypoconnectivity between the left inferior frontal gyrus and the right cerebellum, and hyperconnectivity with the bilateral angular gyrus, anterior cingulate cortex, and left thalamus.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Under the resting condition, dyslexics showed specific hypoconnectivity between the left fusiform gyrus and the posterior cingulate cortex.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/desc.70093","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:56:23Z","timestamp":1763016983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Functional Connectivity Alterations in Developmental Dyslexia: A Meta\u2010Analysis of Task\u2010Based and Resting\u2010State fMRI Studies"],"prefix":"10.1111","volume":"29","author":[{"given":"Junzhe","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-6913","authenticated-orcid":false,"given":"Hong\u2010Yan","family":"Bi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing 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