{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:31:47Z","timestamp":1793932307467,"version":"4.8.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH118362"],"award-info":[{"award-number":["R01 MH118362"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH118362\u201002S1"],"award-info":[{"award-number":["MH118362\u201002S1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH121462\u201001"],"award-info":[{"award-number":["R01MH121462\u201001"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Visual processing undergoes rapid development in the first year of life, supporting the emergence of higher\u2010order cognitive, language, and motor functions. Visual evoked potentials (VEPs) provide a noninvasive measure of visual system maturation that may shed light on heterogeneous developmental trajectories among infants at high familial likelihood for autism. Infants with an older sibling with autism spectrum disorder (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a0177 at 6 months;\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a0132 at 12 months) participated in the Infant Brain Imaging Study\u2013Early Prediction (IBIS\u2010EP) study. Pattern\u2010reversal VEPs were recorded at 6 and 12 months, and developmental skills were assessed at 24 months using the Bayley Scales of Infant and Toddler Development (Bayley\u20104). VEP components (P1 and N1) were characterized by their amplitude and latency, as well as trial\u2010to\u2010trial variability in these measures. Associations with 24\u2010month cognitive, language, and motor scores were examined using general linear models controlling for age, site, sex, and trial count. Robust VEPs were observed at both time points, with age\u2010appropriate morphology and expected developmental changes, including decreases in P1 latency and amplitude from 6 to 12 months. Greater trial\u2010to\u2010trial variability in P1 latency at both time points was associated with higher cognitive and language scores at 24 months. In contrast, conventional measures of mean P1 latency and amplitude were not associated with developmental outcomes. These findings suggest that temporal variability in early visual responses may index adaptive sensory\u2010circuit flexibility during a period of rapid experience\u2010dependent development. VEP response\u2010timing variability may therefore provide an early mechanistic marker of sensory\u2010circuit organization relevant to later developmental trajectories.\n                  <\/jats:p>","DOI":"10.1111\/desc.70266","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T07:20:12Z","timestamp":1786000812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Visual Cortical Response Variability in Infants at High Familial Likelihood for Autism"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1936-2135","authenticated-orcid":false,"given":"Abigail","family":"Dickinson","sequence":"first","affiliation":[{"name":"Center for Autism Research and Treatment, Semel Institute for Neuroscience University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-4816","authenticated-orcid":false,"given":"Madison","family":"Booth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Huberty","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan","family":"Ryan","sequence":"additional","affiliation":[{"name":"Center for Autism Research and Treatment, Semel Institute for Neuroscience University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana","family":"Campbell","sequence":"additional","affiliation":[{"name":"Carolina Institute for Developmental Disabilities, Department of Psychiatry University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9271-0354","authenticated-orcid":false,"given":"Jessica B.","family":"Girault","sequence":"additional","affiliation":[{"name":"Carolina Institute for Developmental Disabilities, Department of Psychiatry University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9362-5656","authenticated-orcid":false,"given":"Neely C.","family":"Miller","sequence":"additional","affiliation":[{"name":"Minnesota Center for Twin and Family Research, Department of Psychology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie K.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8617-2847","authenticated-orcid":false,"given":"John M.","family":"Zempel","sequence":"additional","affiliation":[{"name":"Division of Pediatric &amp; Developmental Neurology, Department of Neurology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4101-6255","authenticated-orcid":false,"given":"Sara Jane","family":"Webb","sequence":"additional","affiliation":[{"name":"Center for Child Health, Behavior and Development Seattle Children's Research Institute  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-1000","authenticated-orcid":false,"given":"Jed T.","family":"Elison","sequence":"additional","affiliation":[{"name":"Institute of Child Development, Department of Pediatrics University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian KC","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Speech and Hearing Sciences, Institute for Learning and Brain Sciences University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette M.","family":"Estes","sequence":"additional","affiliation":[{"name":"Department of Speech and Hearing Sciences, Institute for Learning and Brain Sciences University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-6087","authenticated-orcid":false,"given":"Stephen R.","family":"Dager","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather C.","family":"Hazlett","sequence":"additional","affiliation":[{"name":"Carolina Institute for Developmental Disabilities, Department of Psychiatry University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Educational Psychology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Schultz","sequence":"additional","affiliation":[{"name":"Center for Autism Research, Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Marrus","sequence":"additional","affiliation":[{"name":"Division of Pediatric &amp; Developmental Neurology, Department of Neurology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Evans","sequence":"additional","affiliation":[{"name":"McGill Centre for Integrative Neuroscience, Montreal Neurological Institute McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Piven","sequence":"additional","affiliation":[{"name":"Carolina Institute for Developmental Disabilities, Department of Psychiatry University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John R.","family":"Pruett","sequence":"additional","affiliation":[{"name":"Division of Pediatric &amp; Developmental Neurology, Department of Neurology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafali S.","family":"Jeste","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the IBIS Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2517-14.2016"},{"key":"e_1_2_9_3_1","volume-title":"Bayley\u20104: Scales of Infant and Toddler Development","author":"Bayley N.","year":"2019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-005-0818-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2011.02.018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1669"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/children11060747"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64032-1.00034-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-34669-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.10.009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2024.101425"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.07.026"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.10131"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","unstructured":"Emerson R. W. C.Adams andT.Nishino.2017. \u201cFunctional Neuroimaging of High\u2010Risk 6\u2010Month\u2010Old Infants Predicts a Diagnosis of Autism at 24 Months of Age.\u201dScience.http:\/\/stm.sciencemag.org\/content\/9\/393\/eaag2882.abstract.","DOI":"10.1126\/scitranslmed.aag2882"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2258"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2025.101547"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.21101002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21369"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203837665.ch10"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39242-x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1990.2.2.81"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12328"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcs.128"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(98)01230-3"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2018.42.2.305"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0672-6"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689\u2010017\u20109214\u20109"},{"key":"e_1_2_9_28_1","first-page":"39","volume-title":"Infant EEG and Event\u2010Related Potentials","author":"MCculloch D. L.","year":"2013"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2012.12.011"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2011.00051"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3408-16.2017"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2024.101501"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2023\u2010065297"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010\u20102825"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.131"},{"key":"e_1_2_9_36_1","volume-title":"SCQ. The Social Communication Questionnaire","author":"Rutter M.","year":"2003"},{"key":"e_1_2_9_37_1","volume-title":"Adi\u2010r. Autism Diagnostic Interview Revised. Manual","author":"Rutter M.","year":"2003"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/EB.S130893"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9280.00494"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12360"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203754"}],"container-title":["Developmental Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/desc.70266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/desc.70266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/desc.70266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:29:10Z","timestamp":1790256550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/desc.70266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/desc.70266"],"URL":"https:\/\/doi.org\/10.1111\/desc.70266","archive":["Portico"],"relation":{},"ISSN":["1363-755X","1467-7687"],"issn-type":[{"value":"1363-755X","type":"print"},{"value":"1467-7687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"assertion":[{"value":"2026-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70266"}}