{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:00Z","timestamp":1787014080886,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T00:00:00Z","timestamp":1355270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>\n                    Digit identity has been studied using the chick embryo as a model system for more than 40\u00a0years. Using this model system, several milestone findings have been reported, such as the apical ectodermal ridge (\n                    <jats:styled-content style=\"fixed-case\">AER<\/jats:styled-content>\n                    ), the zone of polarizing activity (\n                    <jats:styled-content style=\"fixed-case\">ZPA<\/jats:styled-content>\n                    ), the\n                    <jats:italic>Shh<\/jats:italic>\n                    gene, and the theory of morphogen and positional information. These experimental results and models provided context for understanding pattern formation in developmental biology. The focus of this review is on the determination of digit identity during limb development. First, the history of studies on digit identity determination is described, followed by descriptions of the molecular mechanisms and current models for determination of digit identity. Finally, future questions and remarkable points will be discussed.\n                  <\/jats:p>","DOI":"10.1111\/dgd.12022","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T01:07:41Z","timestamp":1355274461000},"page":"130-138","source":"Crossref","is-referenced-by-count":29,"title":["How is digit identity determined during limb development?"],"prefix":"10.1111","volume":"55","author":[{"given":"Takayuki","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Biological Science Graduate School of Science Nagoya University Furo\u2010cho Chikusa\u2010ku Nagoya 464\u20108602 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.07.023"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20390"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020216"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513203200"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199801)211:1<88::AID-AJA8>3.0.CO;2-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.037507"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064437"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1185804"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01115"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001083"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0346"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5478.438"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22623"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.10.2997"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.8.2349"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.07.024"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.02.017"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.069492"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.23.9055-9067.2000"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03648"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1157983"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600124103"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01033"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01894"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(95)00156-4"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.01.006"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(73)90002-X"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/358236a0"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.001677"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.14037"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80074-4"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90626-2"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00245"},{"key":"e_1_2_11_36_1","first-page":"309","article-title":"The effect of removing posterior apical ectodermal ridge of the chick wing and leg on pattern formation","volume":"65","author":"Rowe D. 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