{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:26:51Z","timestamp":1761197211111},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>In mammals, the <jats:styled-content style=\"fixed-case\">RXFP<\/jats:styled-content>3 is the cognate receptor of the relaxin\u20103 peptide (<jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3). In teleosts, many different orthologue genes for <jats:styled-content style=\"fixed-case\">RXFP<\/jats:styled-content>3 are present. In particular, two paralogue genes, <jats:italic>rxfp3\u20102a<\/jats:italic> and <jats:italic>rxfp3\u20102b<\/jats:italic>, likely encode the receptors for the <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ln3a peptide. The transcription of these two <jats:italic>rxfp3<\/jats:italic> genes is differentially regulated early during zebrafish embryogenesis. Indeed, reverse transcription\u2013polymerase chain reaction analyses show that the <jats:italic>rxfp3\u20102b<\/jats:italic> transcript is always present during embryo development, while the <jats:italic>rxfp3\u20102a<\/jats:italic> transcript is detectable only at larval stage. By <jats:italic>in situ<\/jats:italic> hybridization experiments on embryos and larvae, the <jats:italic>rxfp3\u20102b<\/jats:italic> transcript was revealed in the brain and in the retinal ganglion cell layer and thymus. Particularly in the brain, many territories are involved in the <jats:italic>rxfp3\u20102b<\/jats:italic> expression, among them the optic tectum, thalamus, preoptic area, different nerve nuclei, habenula and pineal gland. The <jats:styled-content style=\"fixed-case\">RXFP<\/jats:styled-content>3 spatiotemporal expression pattern appears to be conserved between <jats:italic><jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>anio rerio<\/jats:italic> and mammals, as also previously showed for the corresponding ligand, the <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3. Interestingly, the brain areas expressing the <jats:italic>rxfp3\u20102b<\/jats:italic> receptor gene are involved in the visual system, emotional behaviors and circadian rhythm and could be functionally related to the neurotransmitter Rln3a\u2010expressing territories.<\/jats:p>","DOI":"10.1111\/dgd.12093","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T05:21:18Z","timestamp":1382505678000},"page":"766-775","source":"Crossref","is-referenced-by-count":12,"title":["Developmental expression pattern of two zebrafish <i>rxfp3<\/i> paralogue genes"],"prefix":"10.1111","volume":"55","author":[{"given":"Marcella","family":"Fiengo","sequence":"first","affiliation":[{"name":"Department of Biology University of Naples Federico II Via Cinthia 80126 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"del Gaudio","sequence":"additional","affiliation":[{"name":"Department of Biology University of Naples Federico II Via 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