{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:13:28Z","timestamp":1792671208445,"version":"4.5.0"},"reference-count":106,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Neural crest cells (<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>) are a group of multipotent stem cells uniquely present in vertebrates. They are destined to form various organs according to their anterior\u2010posterior (A\u2010P) levels of origin in the neural tube (<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>). They develop into a wide spectrum of cell lineages under the influence of signaling cascades, neural plate border genes and <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content> specifier genes. Although this complex gene regulatory network (<jats:styled-content style=\"fixed-case\">GRN<\/jats:styled-content>) specifies the fate of <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content> and the combinatory action of <jats:italic>Hox<\/jats:italic> genes executed at the time of <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content> induction governs the patterning of <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content> for the formation of specific structures along the A\u2010P axis, not much information on how <jats:styled-content style=\"fixed-case\">GRN<\/jats:styled-content> and <jats:italic>Hox<\/jats:italic> genes directly interact and orchestrate is available. This review summarizes recent findings on the multiple roles of Hoxb5 on the survival and cell lineage differentiation of vagal and trunk <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content> cells during early development, by direct transcriptional regulation of <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content> specifier genes (<jats:italic>Sox9<\/jats:italic> and <jats:italic>Foxd3<\/jats:italic>) of the <jats:styled-content style=\"fixed-case\">GRN<\/jats:styled-content>. We will also review findings on the transcriptional regulation of <jats:italic>Ret<\/jats:italic> by Hoxb5 in the population of the vagal <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content> that are committed to the enteric neuron and glia lineages. Functional redundancy between Hox proteins (Hoxa5 and Hoxc5) from the same paralogue group as Hoxb5, and the cooperative effects of Hox cofactors, collaborators and transcription factors in the Hoxb5 transcriptional regulation of target genes will also be discussed.<\/jats:p>","DOI":"10.1111\/dgd.12199","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T13:15:01Z","timestamp":1424351701000},"page":"158-168","source":"Crossref","is-referenced-by-count":38,"title":["Roles of Hoxb5 in the development of vagal and trunk neural crest cells"],"prefix":"10.1111","volume":"57","author":[{"given":"Mandy K. M.","family":"Kam","sequence":"first","affiliation":[{"name":"Department of Surgery LKS Faculty of Medicine The University of Hong Kong 21 Sassoon Road Pokfulam Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent C. 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