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In this study, we demonstrated that miR\u201029a regulates tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>) mediated bone loss mainly by targeting <jats:styled-content style=\"fixed-case\">DKK<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">GSK<\/jats:styled-content>3<jats:italic>\u03b2<\/jats:italic>, thus activating the Wnt\/\u03b2\u2010catenin pathway. Our findings may provide new insight into the pathogenesis of the bone metabolism disorder in inflammation environment and provide promising therapeutic target.<\/jats:p>","DOI":"10.1111\/dgd.12207","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T22:04:31Z","timestamp":1428012271000},"page":"264-273","source":"Crossref","is-referenced-by-count":23,"title":["miR\u201029a modulates tumor necrosis factor\u2010<i>\u03b1<\/i>\u2010induced osteogenic inhibition by targeting Wnt antagonists"],"prefix":"10.1111","volume":"57","author":[{"given":"Caixia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou 510630 Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou 510630 Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieruo","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou 510630 Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4666(03)00106-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02871"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070207"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1538"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2621"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.11.7739"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100203"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.132852"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.04.252"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22243"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.116137"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.2.275"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.07.027"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210436"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22630"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.03.099"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03319"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23922"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.10.006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37948"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072266"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.07.070"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.05.013"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-4517"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2297"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1798"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1872"}],"updated-by":[{"DOI":"10.1111\/dgd.70072","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:00:00Z","timestamp":1793577600000}}],"container-title":["Development, Growth &amp; 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