{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T21:03:06Z","timestamp":1772744586557,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Circadian rhythms enable organisms to coordinate multiple physiological processes and behaviors with the earth's rotation. In mammals, the suprachiasmatic nuclei (SCN), the sole master circadian pacemaker, has entrainment mechanisms that set the circadian rhythm to a 24\u2010h cycle with photic signals from retina. In contrast, the zebrafish SCN is not a circadian pacemaker, instead the pineal gland (PG) houses the major circadian oscillator. The SCN of flounder larvae, unlike that of zebrafish, however, expresses <jats:italic>per2<\/jats:italic> with a rhythmicity of daytime\/ON and nighttime\/OFF. Here, we examined whether the rhythm of <jats:italic>per2<\/jats:italic> expression in the flounder SCN represents the molecular clock. We also examined early development of the circadian rhythmicity in the SCN and PG. Our three major findings were as follows. First, rhythmic <jats:italic>per2<\/jats:italic> expression in the SCN was maintained under 24\u00a0h dark (DD) conditions, indicating that a molecular clock exists in the flounder SCN. Second, onset of circadian rhythmicity in the SCN preceded that in the PG. Third, both 24\u00a0h light (LL) and DD conditions deeply affected the development of circadian rhythmicity in the SCN and PG. This is the first report dealing with the early development of circadian rhythmicity in the SCN in fish.<\/jats:p>","DOI":"10.1111\/dgd.12222","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T09:23:52Z","timestamp":1432632232000},"page":"444-452","source":"Crossref","is-referenced-by-count":14,"title":["Early development of circadian rhythmicity in the suprachiamatic nuclei and pineal gland of teleost, flounder (<i>Paralichthys olivaeus<\/i>), embryos"],"prefix":"10.1111","volume":"57","author":[{"given":"Makoto","family":"Mogi","sequence":"first","affiliation":[{"name":"Laboratory of Marine Life Science and Genetics Graduate School of Agricultural Science Tohoku University Sendai 981\u20108555 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Uji","sequence":"additional","affiliation":[{"name":"National Research Institute of Aquaculture Farming Biology Division Fisheries Research Agency 422\u20101 Minamiise Watarai Mie 516\u20100193 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Laboratory of Marine Life Science and Genetics Graduate School of Agricultural Science Tohoku University Sendai 981\u20108555 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory of Marine Life Science and Genetics Graduate School of Agricultural Science Tohoku University Sendai 981\u20108555 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-120022414"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.1.01893"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/235781"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0044-8486(99)00074-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35081582"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.183"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80566-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00195961"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.01.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394623-2.00001-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.06.015"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22213"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2007.06.013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80959-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/gcen.2001.7774"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.37"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.719963"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-012-0653-z"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025111"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.07.081"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2009.02500.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2331\/suisan.48.1581"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086176"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-12-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(89)90027-2"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730404269008"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.07.039"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330962"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.01.014"},{"key":"e_1_2_6_31_1","first-page":"555","article-title":"Nonvisual photoreceptors of the deep brain, pineal organs and retina","volume":"17","author":"V\u00edgh B.","year":"2002","journal-title":"Histol. 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