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In this study, we used a simple model vertebrate, the zebrafish, to investigate the functions of <jats:styled-content style=\"fixed-case\">ADAM<\/jats:styled-content>12 during development. Zebrafish <jats:italic>adam12<\/jats:italic> is conserved with those of mammals in the synteny and the amino\u2010acid sequence. We examined <jats:italic>adam12<\/jats:italic> expression in zebrafish embryos by whole mount <jats:italic>in\u00a0situ<\/jats:italic> hybridization and the promoter activity of the <jats:italic>adam12<\/jats:italic> upstream sequence. We found that <jats:italic>adam12<\/jats:italic> is strongly expressed in the cardiovascular system, erythroid progenitors, brain, and jaw cartilage during zebrafish development, and <jats:italic>adam12\u2010<\/jats:italic>knockout zebrafish exhibited reduced body size in the juvenile stage without apparent morphological defects. Taken together, these results suggest that <jats:italic>adam12<\/jats:italic> plays a significant role in the regulation of body growth during juvenile stage in zebrafish, although the precise molecular mechanisms await further study.<\/jats:p>","DOI":"10.1111\/dgd.12286","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T02:46:59Z","timestamp":1463453219000},"page":"409-421","source":"Crossref","is-referenced-by-count":15,"title":["ADAM12\u2010deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects"],"prefix":"10.1111","volume":"58","author":[{"given":"Yudai","family":"Tokumasu","sequence":"first","affiliation":[{"name":"Department of Growth Regulation Institute for Frontier Medical Sciences Kyoto University Shogo\u2010in Kawahara\u2010cho 53 Sakyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Growth Regulation Institute for Frontier Medical Sciences Kyoto University Shogo\u2010in Kawahara\u2010cho 53 Sakyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Growth Regulation Institute for Frontier Medical Sciences Kyoto University Shogo\u2010in Kawahara\u2010cho 53 Sakyo\u2010ku Japan"},{"name":"Laboratory of Functional Biology Kyoto University Graduate School of Biostudies Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ansai","sequence":"additional","affiliation":[{"name":"Division of Applied Biosciences Graduate School of Agriculture Kyoto University Kitashirakawa\u2010Oiwake\u2010cho Sakyo\u2010ku Kyoto 606\u20108502 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Division of Applied Biosciences Graduate School of Agriculture Kyoto University Kitashirakawa\u2010Oiwake\u2010cho Sakyo\u2010ku Kyoto 606\u20108502 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Sehara\u2010Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Growth Regulation Institute for Frontier Medical Sciences Kyoto University Shogo\u2010in Kawahara\u2010cho 53 Sakyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5394.1711"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.20148177"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0102-35"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1550"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.23.10713"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2848"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605451200"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.08.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.571414"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-547182"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh458"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121558"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-7-63"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2501"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.04.052"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.08.014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.06.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2009.02.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00043-4"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.1.55-61.2003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.091702"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0711"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2004.06.003"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1082"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1242\/dev.123.1.357","article-title":"Mutations affecting craniofacial development in zebrafish","volume":"123","author":"Neuhauss S. 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