{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:05Z","timestamp":1787014085005,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005989","name":"Ministrstvo za Izobra\u017eevanje, Znanost in \u0160port","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005989","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>\n                    <jats:italic>Zfp318<\/jats:italic>\n                    , a mouse gene with a Cys2\/His2 zinc finger motif, is mainly expressed in germ cells in the testis. It encodes two alternative transcripts, which regulate androgen receptor\u2010mediated transcriptional activation or repression by overexpression of them. However, the role of\n                    <jats:italic>Zfp318<\/jats:italic>\n                    is still obscure\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    , especially in spermatogenesis. To elucidate the role of\n                    <jats:italic>Zfp318<\/jats:italic>\n                    during gamete production, we established a knockout mouse line.\n                    <jats:italic>Zfp318<\/jats:italic>\n                    \u2010null male mice exhibited infertility, whereas\n                    <jats:italic>Zfp318<\/jats:italic>\n                    \u2010null female mice displayed normal fertility.\n                    <jats:styled-content style=\"fixed-case\">ZFP<\/jats:styled-content>\n                    318 was expressed during multiple stages of spermatogenesis, from spermatocytes to round spermatids. The nuclei of secondary spermatocytes showed high levels of expression. Histological analysis and quantitative analysis of\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    content showed decreased numbers of both spermatids in the seminiferous tubules and\u00a0mature spermatozoa in the epididymides of\n                    <jats:italic>Zfp318<\/jats:italic>\n                    \u2010null mice. These results suggest that\n                    <jats:italic>Zfp318<\/jats:italic>\n                    is\u00a0expressed as a functional protein in testicular germ cells and plays an important role in meiosis during spermatogenesis.\n                  <\/jats:p>","DOI":"10.1111\/dgd.12301","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T05:39:05Z","timestamp":1467869945000},"page":"600-608","source":"Crossref","is-referenced-by-count":27,"title":["Abnormal spermatogenesis and male infertility in testicular zinc finger protein\n                    <i>Zfp318<\/i>\n                    \u2010knockout mice"],"prefix":"10.1111","volume":"58","author":[{"given":"Masamichi","family":"Ishizuka","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Tokyo Institute of Technology Yokohama 226\u20108501 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