{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:07:05Z","timestamp":1763705225554},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Regeneration of lost organs involves complex processes, including host defense from infection and rebuilding of lost tissues. We previously reported that <jats:italic>Xenopus<\/jats:italic> neuronal pentraxin I (<jats:italic><jats:styled-content style=\"fixed-case\">xNP<\/jats:styled-content>1<\/jats:italic>) is expressed preferentially in regenerating <jats:italic>Xenopus laevis<\/jats:italic> tadpole tails. To evaluate <jats:italic><jats:styled-content style=\"fixed-case\">xNP<\/jats:styled-content>1<\/jats:italic> function in tail regeneration, and also in tail development, we analyzed <jats:italic><jats:styled-content style=\"fixed-case\">xNP<\/jats:styled-content>1<\/jats:italic> expression in tailbud embryos and regenerating\/healing tails following tail amputation in the \u2018regeneration\u2019 period, as well as in the \u2018refractory\u2019 period, when tadpoles lose their tail regenerative ability. Within 10\u00a0h after tail amputation, <jats:italic><jats:styled-content style=\"fixed-case\">xNP<\/jats:styled-content>1<\/jats:italic> was induced at the amputation site regardless of the tail regenerative ability, suggesting that <jats:styled-content style=\"fixed-case\">xNP<\/jats:styled-content>1 functions in acute phase responses. <jats:italic><jats:styled-content style=\"fixed-case\">xNP<\/jats:styled-content>1<\/jats:italic> was widely expressed in regenerating tails, but not in the tail buds of tailbud embryos, suggesting its possible role in the immune response\/healing after an injury. <jats:italic><jats:styled-content style=\"fixed-case\">xNP<\/jats:styled-content>1<\/jats:italic> expression was also observed in neural tissues\/primordia in tailbud embryos and in the spinal cord in regenerating\/healing tails in both periods, implying its possible roles in neural development or function. Moreover, during the first 48\u00a0h after amputation, <jats:italic><jats:styled-content style=\"fixed-case\">xNP<\/jats:styled-content>1<\/jats:italic> expression was sustained at the spinal cord of tails in the \u2018regeneration\u2019 period tadpoles, but not in the \u2018refractory\u2019 period tadpoles, suggesting that <jats:italic><jats:styled-content style=\"fixed-case\">xNP<\/jats:styled-content>1<\/jats:italic> expression at the spinal cord correlates with regeneration. Our findings suggest that <jats:styled-content style=\"fixed-case\">xNP<\/jats:styled-content>1 is involved in both acute phase responses and neural development\/functions, which is unique compared to mammalian pentraxins whose family members are specialized in either acute phase responses or neural functions.<\/jats:p>","DOI":"10.1111\/dgd.12326","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T09:17:14Z","timestamp":1478078234000},"page":"688-701","source":"Crossref","is-referenced-by-count":6,"title":["Acute phase response in amputated tail stumps and neural tissue\u2010preferential expression in tail bud embryos of the <i>Xenopus<\/i> neuronal pentraxin I gene"],"prefix":"10.1111","volume":"58","author":[{"given":"Yuko","family":"Hatta\u2010Kobayashi","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Graduate School of Science The University of Tokyo Bunkyo\u2010ku Tokyo 113\u20100033 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