{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:25:35Z","timestamp":1740137135579,"version":"3.37.3"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["25461632"],"award-info":[{"award-number":["25461632"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p><jats:italic><jats:styled-content style=\"fixed-case\">FOXC<\/jats:styled-content>2<\/jats:italic>, a forkhead transcriptional factor, is a candidate gene for congenital heart diseases and lymphedema\u2010distichiasis syndrome and yellow nail syndrome; however, there are no reports on <jats:italic>Foxc2<\/jats:italic> and the development of the lung. We have identified lung abnormalities in <jats:italic>Foxc2<\/jats:italic>\u2010knockout embryos during investigation of cardiac development. The aim of this study was to clarify the morphological characteristics during lung development using <jats:styled-content style=\"fixed-case\">ICR<\/jats:styled-content>\u2010<jats:italic>Foxc2<\/jats:italic> knockout lungs. Mutant fetuses at embryonic days 10.5\u201318.5 were obtained from mating of <jats:italic>Foxc2<\/jats:italic><jats:sup><jats:italic>+\/\u2212<\/jats:italic><\/jats:sup> mice and then analyzed. Notably, <jats:italic>Foxc2<\/jats:italic>\u2010knockout lungs appeared parenchymatous and much smaller than those of the wild\u2010type littermates. In the <jats:italic>Foxc2<\/jats:italic> knockout lungs, the capillary beds remained distant from the alveolar epithelium until the late stages, the number of type2 alveolar cells per alveolar progenitor cell was lower and the type1 alveolar cells were thicker in <jats:italic>Foxc2<\/jats:italic> knockout mice. In contrast, <jats:italic>Foxc2<\/jats:italic> expression was only detected in the mesenchyme of the lung buds at E10.5, and it disappeared at E11.5 in <jats:italic>Foxc2\u2010LacZ<\/jats:italic> knockin mice. Furthermore, the expression of Lef1 was significantly inhibited in E11.5 lungs. All of these results suggest that the abnormalities in <jats:italic>Foxc2<\/jats:italic> knockout mice may involve maldifferentiation of alveolar epithelial cells and capillary vessel endothelial\u2010alveolar epithelial approach as well as lymph vessel malformation. This is the first report about relationship between <jats:italic>Foxc2<\/jats:italic> and lung development. This animal model might provide an important clue for elucidating the mechanism of lung development and the cause of respiratory diseases.<\/jats:p>","DOI":"10.1111\/dgd.12368","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T13:35:42Z","timestamp":1499175342000},"page":"501-514","source":"Crossref","is-referenced-by-count":4,"title":["<i>Foxc2<\/i> influences alveolar epithelial cell differentiation during lung development"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1526-7878","authenticated-orcid":false,"given":"Mayoko","family":"Tsuji","sequence":"first","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masae","family":"Morishima","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichi","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Heglind","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Cell Biology Institute of Biomedicine University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Enerb\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Cell Biology Institute of Biomedicine University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Ezaki","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tamaoki","sequence":"additional","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.4.789"},{"key":"e_1_2_6_3_1","first-page":"187","article-title":"Differential and specific labeling of epithelial and vascular endothelial cells of the rat lung by Lycopersicon esculentum and Griffonia simplicifolia I lectins","volume":"54","author":"Bankston P. 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