{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:07:24Z","timestamp":1790388444599,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005683","name":"Kyoto University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005683","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>The adrenal gland is an endocrine organ that plays essential roles in stress responses. This organ consists of two types of tissues, adrenomedulla and adrenocortex, deriving from different embryonic origins. Whereas it is well accepted that the adrenomedulla derives from neural crest cells, the origin of the adrenocortex remains elusive. In addition, the adrenocortex and gonads, two major steroid hormone\u2010producing tissues, have been thought to share the same origin, although the experimental evidence is lacking. In this study, to identify the origin of adrenocortex and to compare it to that of gonads, we scrutinized the medial portion of the coelomic epithelium (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>) after the lateral plate mesoderm has split into two <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> components with a concomitant opening of the coelomic cavity in between them. We found that early medial <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> consists of a two\u2010cell layer\u2010thick band of epithelial\u2010like cells, the outer and inner <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>s. The outer <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> faces the coelomic cavity, whereas the inner <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> is juxtaposed to nascent blood vessels. Combining direct cell labeling with early molecular markers, we found that outer <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> was the origin of the gonad but not the adrenocortex. The adrenocortex, instead, appears to derive from inner <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>. Thus, the adrenocortical and gonadal progenitors are already segregated from each other when the coelomic cavity has opened. This study provides a new basis for understanding how the adrenal gland forms and how steroid hormone\u2010producing tissues arise during development.<\/jats:p>","DOI":"10.1111\/dgd.12389","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T07:31:55Z","timestamp":1502955115000},"page":"593-602","source":"Crossref","is-referenced-by-count":9,"title":["Early segregation of the adrenal cortex and gonad in chicken embryos"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5999-2505","authenticated-orcid":false,"given":"Daisuke","family":"Saito","sequence":"first","affiliation":[{"name":"Frontier Research Institute for Interdisciplinary Sciences (FRIS) Tohoku University Aoba\u2010ku, Sendai 980\u20108578 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Neurosciences Graduate School of Life Sciences Tohoku University Aoba\u2010ku, Sendai 980\u20108578"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Zoology Graduate School of Science Kyoto University Kitashirakawa, Sakyo\u2010ku Kyoto Japan"},{"name":"AMED Core Research for Evolutional Science and Technology (AMED\u2010CREST) Japan Agency for Medical Research and Development (AMED) Chiyoda\u2010ku Tokyo 100\u20100004 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24373"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21189"},{"key":"e_1_2_6_4_1","first-page":"195","article-title":"The development of the adrenal gland in man with special reference to origin and ultimate location of cell types and evidence in favor of \u201ccell\u2010migration\u201d theory","volume":"251","author":"Crowder R. E.","year":"1957","journal-title":"Cotrib. Embryol."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.2005.00815.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.18.4129"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050700210"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.1996.00254.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.7.7.852"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2307\/1292332"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.9068"},{"key":"e_1_2_6_13_1","first-page":"481","article-title":"Localization, by the method of interspecific grafts of the neural area from which adrenal cells arise in the bird embryo","volume":"272","author":"Douarin N.","year":"1971","journal-title":"C. R. Acad. Sci. Hebd. Seances. Acad. Sci. D."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.9.1653"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10153"},{"key":"e_1_2_6_16_1","first-page":"269","article-title":"Gonadal development of the chick embryo following microsurgically caused agenesis of the mesonephros and using interspecific quail\u2010chick chimaeras","volume":"98","author":"Rodemer E. S.","year":"1986","journal-title":"J. Embryol. Exp. 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