{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:22:15Z","timestamp":1768486935310,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>When anuran tadpoles are treated with vitamin A after tail amputation, hindlimb\u2010like structures can be generated instead of the lost tail part at the amputation site. This homeotic transformation was initially expected to be a key to understanding the body plan of vertebrates. Unfortunately, homeotic limb formation has been reproduced in only some Indian frog species and a European species, but not in experimental anurans such as <jats:italic>Xenopus laevis<\/jats:italic> or <jats:italic>Rana catesbeiana<\/jats:italic>. Consequently, this fascinating phenomenon has not been well analyzed, especially at the molecular level. In addition, the initial processes of ectopic limb development are also unclear because morphological changes in the early phases have not been analyzed in detail. In this study, we report the induction of homeotic transformation using Japanese brown frogs and present a detailed morphological analysis. Unexpectedly, the ectopic limbs developed not only at the ventral sites, but also at the dorsal sites of the tail regenerates of vitamin A\u2010treated tadpoles. The relationship between position and axial orientation of ectopic limbs suggested the double duplication of positional value order along the rostral\u2010caudal axis and the dorsal\u2010ventral axis of the tail regenerates.<\/jats:p>","DOI":"10.1111\/dgd.12407","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T02:38:42Z","timestamp":1509590322000},"page":"688-700","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin A induced homeotic hindlimb formation on dorsal and ventral sides of regenerating tissue of amputated tails of Japanese brown frog tadpoles"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8427-8955","authenticated-orcid":false,"given":"Ichiro","family":"Tazawa","sequence":"first","affiliation":[{"name":"Division of Embryology Amphibian Research Center Hiroshima University Higashihiroshima 739\u20108526 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Yaoita","sequence":"additional","affiliation":[{"name":"Division of Embryology Amphibian Research Center Hiroshima University Higashihiroshima 739\u20108526 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2108\/zs1400262"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1096-3642.1881.tb01323.x","article-title":"On the development of the skeleton of the paired fins of Elasmobranchii, considered in relation to its bearing on the nature of the limbs of the Vertebrata","volume":"1881","author":"Balfour F. 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