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In testicular seminiferous tubules, spermatogenic stem cells (<jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>s) are highly motile and are interspersed between their differentiating progeny, while undergoing self\u2010renewal and differentiation. In such an \u201copen niche\u201d microenvironment, some<jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>s proliferate, while others exit the stem cell compartment through differentiation; therefore, self\u2010renewal and differentiation are perfectly balanced at the population (or tissue) level, a dynamics termed \u201cpopulation asymmetry.\u201d This is in stark contrast to the classical perception of tissue stem cells being cells that are clustered in a specialized \u201cclosed niche\u201d region and that invariantly undergo asymmetric divisions. However, despite its importance, how the self\u2010renewal and differentiation of<jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>s are balanced in an open niche environment is poorly understood. Recent studies have thrown light on the key mechanism that enables<jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>s to follow heterogeneous fates, although they are equally exposed to signaling molecules controlling self\u2010renewal and differentiation. In particular,<jats:styled-content style=\"fixed-case\">SSC<\/jats:styled-content>s show heterogeneous susceptibilities to differentiation\u2010promoting signals such as Wnt and retinoic acid. Heterogeneous susceptibility to the ubiquitously distributed fate\u2010controlling extracellular signal might be a key generic mechanism for the heterogeneous fate of tissue stem cells in open niche microenvironments.<\/jats:p>","DOI":"10.1111\/dgd.12574","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T07:03:31Z","timestamp":1542351811000},"page":"542-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Open niche regulation of mouse spermatogenic stem cells"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-1866","authenticated-orcid":false,"given":"Shosei","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Germ Cell Biology National Institute for Basic Biology National Institutes of Natural Sciences Okazaki Japan"},{"name":"Department of Basic Biology School of Life Science SOKENDAI (Graduate University for Advanced Studies) Okazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.113.113555"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2065"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1097676"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161371"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.240465.114"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.04.010"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1517994113"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0074-y"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.4.1179"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1260669"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod65.4.1170"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05574"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000930308"},{"key":"e_1_2_11_15_1","first-page":"281","article-title":"Spermatogonial stem cell renewal in the mouse. 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