{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:56:42Z","timestamp":1779893802405,"version":"3.53.1"},"reference-count":39,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H07237"],"award-info":[{"award-number":["JP16H07237"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K08498"],"award-info":[{"award-number":["JP17K08498"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Zebrafish have the ability to regenerate skeletal structures, including the fin, skull roof, and jaw. Although fin regeneration proceeds by epimorphic regeneration, it remains unclear whether this process is involved in other skeletal regeneration in zebrafish. Initially in epimorphic regeneration, the wound epidermis covers the wound surface. Subsequently, the blastema, an undifferentiated mesenchymal mass, forms beneath the epidermis. In the present study, we re\u2010examined the regeneration of the zebrafish lower jaw in detail, and investigated whether epimorphic regeneration is involved in this process. We performed amputation of the lower jaw at two different positions; the proximal level (presence of Meckel's cartilage) and the distal level (absence of Meckel's cartilage). In both manipulations, a blastema\u2010like cellular mass was initially formed. Subsequently, cartilaginous aggregates were formed in this mass. In the proximal amputation, the cartilaginous aggregates were then fused with Meckel's cartilage and remained as a skeletal component of the regenerated jaw, whereas in the distal amputation, the cartilaginous aggregates disappeared as regeneration progressed. Two molecules that were observed during epimorphic regeneration, Laminin and <jats:italic>msxb,<\/jats:italic> were expressed in the regenerating lower jaw, although the domain of <jats:italic>msxb<\/jats:italic> expression was out of the main plain of the aggregate formation. Administration of an inhibitor of Wnt\/\u03b2\u2010catenin signaling, a pathway associated with epimorphic regeneration, showed few effects on lower jaw regeneration. Our finding suggests that skeletal regeneration of the lower jaw mainly progresses through tissue regeneration that is dependent on the position in the jaw, and epimorphic regeneration plays an adjunctive role in this regeneration.<\/jats:p>","DOI":"10.1111\/dgd.12625","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:36:31Z","timestamp":1567125391000},"page":"419-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Tissue regeneration during lower jaw restoration in zebrafish shows some features of epimorphic regeneration"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3272-1457","authenticated-orcid":false,"given":"Shiro","family":"Ohgo","sequence":"first","affiliation":[{"name":"Department of Applied Biological Science Tokyo University of Science Noda Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Ichinose","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Science Tokyo University of Science Noda Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinako","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Science Tokyo University of Science Noda Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Sato\u2010Maeda","sequence":"additional","affiliation":[{"name":"Frontier Research Institute for Interdisciplinary Sciences Tohoku University Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Shoji","sequence":"additional","affiliation":[{"name":"Frontier Research Institute for Interdisciplinary Sciences Tohoku University Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Science Tokyo University of Science Noda Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"issue":"2","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1242\/dev.121.2.347","article-title":"Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish","volume":"121","author":"Akimenko M.\u2010A.","year":"1995","journal-title":"Development (Cambridge, England)"},{"key":"e_1_2_6_3_1","volume-title":"Principles of regenerative biology","author":"Carlson B. 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