{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:20:30Z","timestamp":1790803230437,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H04185"],"award-info":[{"award-number":["17H04185"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K17691"],"award-info":[{"award-number":["19K17691"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The respiratory system has ideal tissue structure and cell types for efficient gas exchange to intake oxygen and release carbon dioxide. This complex system develops through orchestrated intercellular signaling among various cell types, such as club, ciliated, basal, neuroendocrine, <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>2, endothelial, and smooth muscle cells. Notch signaling is a highly conserved cell\u2013cell signaling pathway ideally suited for very short\u2010range cellular communication because Notch signals are transmitted by direct contact with an adjacent cell. Enthusiastic efforts by Notch researchers over the last two decades have led to the identification of critical roles of this signaling pathway during development, homeostasis, and regeneration of the respiratory system. The dysregulation of Notch signaling results in a wide range of respiratory diseases such as pulmonary artery hypertension (<jats:styled-content style=\"fixed-case\">PAH<\/jats:styled-content>), chronic obstructive pulmonary disease (<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>), interstitial pulmonary fibrosis (<jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content>), and lung cancer. Thus, a deep understanding of the biological functions of Notch signaling will help identify novel treatment targets in various respiratory diseases.<\/jats:p>","DOI":"10.1111\/dgd.12628","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T12:32:01Z","timestamp":1571142721000},"page":"67-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["Notch signaling in the mammalian respiratory system, specifically the trachea and lungs, in development, homeostasis, regeneration, and disease"],"prefix":"10.1111","volume":"62","author":[{"given":"Hirofumi","family":"Kiyokawa","sequence":"first","affiliation":[{"name":"Laboratory for Lung Development and Regeneration RIKEN Center for Biosystems Dynamics Research Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Laboratory for Lung Development and Regeneration RIKEN Center for Biosystems Dynamics Research Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0140OC"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2013.01.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/386852a0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.06.081"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.20121701"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2009"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06412"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.12.017"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206230"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.16.1355"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14664"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1204710109"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.029249"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.21.11872"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.098186"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.07.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.6.4498"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63147-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.18.3913"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290016"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3642"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.039"},{"issue":"1149","key":"e_1_2_6_24_1","first-page":"e1112","article-title":"Anatomically and functionally distinct lung mesenchymal populations marked by Lgr5 and Lgr6","volume":"170","author":"Lee J. 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