{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:15:01Z","timestamp":1789096501012,"version":"build-2803163510"},"reference-count":72,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P01 HD093363"],"award-info":[{"award-number":["P01 HD093363"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1R01DK123092"],"award-info":[{"award-number":["1R01DK123092"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dev Growth Differ"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ventx2 is an Antennapedia superfamily\/NK\u2010like subclass homeodomain transcription factor best known for its roles in the regulation of early dorsoventral patterning during\n                    <jats:italic>Xenopus<\/jats:italic>\n                    gastrulation and in the maintenance of neural crest multipotency. In this work we characterize the spatiotemporal expression pattern of\n                    <jats:italic>ventx2<\/jats:italic>\n                    in progenitor cells of the\n                    <jats:italic>Xenopus<\/jats:italic>\n                    respiratory system epithelium. We find that\n                    <jats:italic>ventx2<\/jats:italic>\n                    is directly induced by BMP signaling in the ventral foregut prior to\n                    <jats:italic>nkx2\u20101<\/jats:italic>\n                    , the earliest epithelial marker of the respiratory lineage. Functional studies demonstrate that Ventx2 regulates the number of Nkx2\u20101\/Sox9+ respiratory progenitor cells induced during foregut development, the timing and level of surfactant protein gene expression, and proper tracheal\u2013esophageal separation. Our data suggest that Ventx2 regulates the balance of respiratory progenitor cell expansion and differentiation. While the\n                    <jats:italic>ventx<\/jats:italic>\n                    gene family has been lost from the mouse genome during evolution, humans have retained a\n                    <jats:italic>ventx2<\/jats:italic>\n                    \u2010like gene (\n                    <jats:italic>VENTX<\/jats:italic>\n                    ). Finally, we discuss how our findings might suggest a possible function of\n                    <jats:italic>VENTX<\/jats:italic>\n                    in human respiratory progenitor cells.\n                  <\/jats:p>","DOI":"10.1111\/dgd.12807","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T23:34:06Z","timestamp":1661816046000},"page":"347-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The homeodomain transcription factor\n                    <i>Ventx2<\/i>\n                    regulates respiratory progenitor cell number and differentiation timing during\n                    <i>Xenopus<\/i>\n                    lung development"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3953-6016","authenticated-orcid":false,"given":"Scott A.","family":"Rankin","sequence":"first","affiliation":[{"name":"Center for Stem Cell and Organoid Medicine (CuSTOM), Division of Developmental Biology, Perinatal Institute Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3217-3590","authenticated-orcid":false,"given":"Aaron M.","family":"Zorn","sequence":"additional","affiliation":[{"name":"Center for Stem Cell and Organoid Medicine (CuSTOM), Division of Developmental Biology, Perinatal Institute Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA"},{"name":"University of Cincinnati College of Medicine, Department of Pediatrics Cincinnati Ohio 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