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Guamanian parkinsonism dementia with amyotrophic sclerosis is a local case of Parkinson's disease reported in the Western Pacific Islands of Guam and Rota as well as in the Kii Peninsula of Japan. A previous genetic study has suggested that Guamanian parkinsonism is attributable to a variant of the <jats:italic>TRPM7<\/jats:italic> gene, which encodes for melastatin\u2010related transient receptor potential (TRP) ion channels. But the link between parkinsonism and the <jats:italic>TRPM7<\/jats:italic> gene remains elusive. Previous studies have addressed that <jats:italic>trpm7<\/jats:italic>\u2010deficient zebrafish embryos showed defects in pigmentation and touch\u2010evoked motor response. In this study, we identified a new viable allele of <jats:italic>trpm7<\/jats:italic> mutant causing an I756N amino acid substitution in the first transmembrane domain. Behavioral analyses revealed that <jats:italic>trpm7<\/jats:italic> mutants showed compromised motility with their movement distance shorter than wild\u2010type larvae. The velocity of the movement was significantly reduced in <jats:italic>trpm7<\/jats:italic> mutants than in wild\u2010type larvae. Along with a previous finding of reduced dopaminergic neurons in zebrafish <jats:italic>trpm7<\/jats:italic> mutants, reduced motility of <jats:italic>trpm7<\/jats:italic> mutants can suggest another similarity between <jats:italic>trpm7<\/jats:italic> phenotypes and Parkinson's disease symptoms.<\/jats:p>","DOI":"10.1111\/dgd.12937","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T07:53:20Z","timestamp":1720252400000},"page":"349-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Zebrafish <scp><i>trpm7<\/i><\/scp> mutants show reduced motility in free movement"],"prefix":"10.1111","volume":"66","author":[{"given":"Kenta","family":"Watai","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biological Science, College of Science and Engineering Aoyama Gakuin University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Sadamitsu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biological Science, College of Science and Engineering Aoyama Gakuin University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biological Science, College of Science and Engineering Aoyama Gakuin University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-9033","authenticated-orcid":false,"given":"Makoto","family":"Kashima","sequence":"additional","affiliation":[{"name":"Faculty of Science Toho University  Funabashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3769-7441","authenticated-orcid":false,"given":"Hiromi","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biological Science, College of Science and Engineering Aoyama Gakuin University  Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2004.06.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2412"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00777-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2004.06.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.11.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.02.050"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(86)90116-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2119630119"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30966"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505149102"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1157-13.2013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01410"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.004531"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2952"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163493"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120033109"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4950-10.2011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700710"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-437X(93)90102-U"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93909-y"},{"key":"e_1_2_8_23_1","first-page":"617","article-title":"Amyotrophic lateral sclerosis\u2010parkinsonism\u2010dementia complex of Guam. 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