{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T09:20:51Z","timestamp":1761384051024,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Development, Growth &amp; Differentiation"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Anuran tadpoles regenerate their tails after amputation. However, when vitamin A is administered, some anuran species such as\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Rana ornativentris<\/jats:italic>\n                    <\/jats:styled-content>\n                    occasionally form ectopic limbs instead of tail. Few analyses of this phenomenon at the molecular level exist. To investigate the molecular mechanisms underlying ectopic limb development, we quantified the expression of genes related to normal limb positioning and development. We observed the downregulation of a posterior\n                    <jats:italic>hox<\/jats:italic>\n                    gene prior to the appearance of ectopic limb buds in the regenerating tail. This\n                    <jats:italic>hox<\/jats:italic>\n                    expression change also preceded the upregulation of\n                    <jats:italic>pitx<\/jats:italic>\n                    1, which is expressed in the earliest hind limb bud. These results suggest that Hox genes are involved in ectopic limb induction upstream of hind limb genes.\n                  <\/jats:p>","DOI":"10.1111\/dgd.70027","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T02:49:49Z","timestamp":1759891789000},"page":"446-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression of\n                    <i>hox<\/i>\n                    Genes and Genes Related to Limb Development During the Homeotic Transformation of Tails Into Limbs Induced by Vitamin A in the Anuran\n                    <i>Rana ornativentris<\/i>"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4697-3103","authenticated-orcid":false,"given":"Sho","family":"Morioka","sequence":"first","affiliation":[{"name":"Hiroshima University Amphibian Research Center  Higashi\u2010Hiroshima City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Yaoita","sequence":"additional","affiliation":[{"name":"Hiroshima University Amphibian Research Center  Higashi\u2010Hiroshima City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-9179","authenticated-orcid":false,"given":"Keisuke","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Hiroshima University Amphibian Research Center  Higashi\u2010Hiroshima City Japan"},{"name":"Program of Basic Biology, Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Furuno","sequence":"additional","affiliation":[{"name":"Hiroshima University Amphibian Research Center  Higashi\u2010Hiroshima City Japan"},{"name":"Program of Basic Biology, Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8427-8955","authenticated-orcid":false,"given":"Ichiro","family":"Tazawa","sequence":"additional","affiliation":[{"name":"Hiroshima University Amphibian Research Center  Higashi\u2010Hiroshima City Japan"},{"name":"Program of Basic Biology, Graduate School of Integrated Sciences for Life Hiroshima University  Higashi\u2010Hiroshima City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(92)90152-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.2.333"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20140061"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.11.1910"},{"volume-title":"Guidebook to the Homeobox Genes","year":"1994","author":"Gehring W. 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