{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:44:32Z","timestamp":1791110672290,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T00:00:00Z","timestamp":1352937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>Aim\u2002<\/jats:bold> We aimed to investigate the induction of long\u2010term potentiation (LTP)\u2010like plasticity by paired associative stimulation (PAS) in patients with high\u2010functioning autism and Asperger syndrome (HFA\/AS).<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> PAS with an interstimulus interval between electrical and transcranial magnetic stimulation of 25\u2003ms (PAS<jats:sub>25<\/jats:sub>) was performed in patients with HFA\/AS (<jats:italic>n<\/jats:italic>=9; eight males, one female; mean age 17y 11mo, SD 4y 5mo) and in typically developing age\u2010matched volunteers (<jats:italic>n<\/jats:italic>=9; five males, four females; mean age 22y 4mo, SD 5y 2mo). The amplitude of motor\u2010evoked potentials was measured before PAS<jats:sub>25<\/jats:sub>, immediately after stimulation, and 30 minutes and 60 minutes later. A PAS protocol adapted to individual N20 latency (PAS<jats:sub>N20+2<\/jats:sub>) was performed in six additional patients with HFA\/AS. Short\u2010interval intracortical inhibition was measured using paired\u2010pulse stimulation.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In contrast to the typically developing participants, the patients with HFA\/AS did not show a significant increase in motor\u2010evoked potentials after PAS<jats:sub>25<\/jats:sub>. This finding could also be demonstrated after adaptation for N20 latency. Short\u2010interval intracortical inhibition of patients with HFA\/AS was normal compared with the comparison group and did not correlate with PAS effect.<\/jats:p><jats:p><jats:bold>Interpretation\u2002<\/jats:bold> Our results show a significant impairment of LTP\u2010like plasticity induced by PAS in individuals with HFA\/AS compared with typically developing participants. This finding is in accordance with results from animal studies as well as human studies. Impaired LTP\u2010like plasticity in patients with HFA\/AS points towards reduced excitatory synaptic connectivity and deficits in sensory\u2010motor integration in these patients.<\/jats:p>","DOI":"10.1111\/dmcn.12012","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T15:04:07Z","timestamp":1353078247000},"page":"83-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Impaired induction of long\u2010term potentiation\u2010like plasticity in patients with high\u2010functioning autism and Asperger syndrome"],"prefix":"10.1111","volume":"55","author":[{"given":"NIKOLAI H","family":"JUNG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WIBKE G","family":"JANZARIK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IGOR","family":"DELVENDAHL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALEXANDER","family":"M\u00dcNCHAU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MONICA","family":"BISCALDI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FLORIAN","family":"MAINBERGER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOBIAS","family":"B\u00c4UMER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"REINHOLD","family":"RAUH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VOLKER","family":"MALL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,15]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-010-0981-3"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-006-0235-6"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-009-0057-0"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2009.03270.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp088"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05603.x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5491.533"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1019-09.2009"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2623-05.2006"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.4161\/epi.1.4.3514"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086446"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09582"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03665.x"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.3.572"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-424X(09)70395-2"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi116"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5016-03.2004"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-008-0646-7"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.09.021"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019912"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-17-07000.1998"},{"key":"e_1_2_8_24_2","volume-title":"International Classification of Diseases, 10th revision (ICD\u201010)","author":"World Health Organization","year":"1994"},{"key":"e_1_2_8_25_2","volume-title":"[Basic intelligence test scale 2 (CFT 20). 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