{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:33:14Z","timestamp":1785817994206,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,4]],"date-time":"2012-11-04T00:00:00Z","timestamp":1351987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p><jats:bold>Aim\u2002<\/jats:bold>We report three cases of Landau\u2013Kleffner syndrome (LKS) in children (two females, one male) in whom diagnosis was delayed because the sleep electroencephalography (EEG) was initially normal.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold>Case histories including EEG, positron emission tomography findings, and long\u2010term outcome were reviewed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Auditory agnosia occurred between the age of 2\u2003years and 3\u2003years 6\u2003months, after a period of normal language development. Initial awake and sleep EEG, recorded weeks to months after the onset of language regression, during a nap period in two cases and during a full night of sleep in the third case, was normal. Repeat EEG between 2\u2003months and 2\u2003years later showed epileptiform discharges during wakefulness and strongly activated by sleep, with a pattern of continuous spike\u2010waves during slow\u2010wave sleep in two patients. Patients were diagnosed with LKS and treated with various antiepileptic regimens, including corticosteroids. One patient in whom EEG became normal on hydrocortisone is making significant recovery. The other two patients did not exhibit a sustained response to treatment and remained severely impaired.<\/jats:p><jats:p><jats:bold>Interpretation\u2002<\/jats:bold>Sleep EEG may be normal in the early phase of acquired auditory agnosia. EEG should be repeated frequently in individuals in whom a firm clinical diagnosis is made to facilitate early treatment.<\/jats:p>","DOI":"10.1111\/dmcn.12025","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T04:26:50Z","timestamp":1352089610000},"page":"575-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Acquired auditory agnosia in childhood and normal sleep electroencephalography subsequently diagnosed as Landau\u2013Kleffner syndrome: a report of three cases"],"prefix":"10.1111","volume":"55","author":[{"given":"PATRICK","family":"VAN BOGAERT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARY D","family":"KING","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHILIPPE","family":"PAQUIER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CATHERINE","family":"WETZBURGER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CATHERINE","family":"LABASSE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEAN\u2010MARIE","family":"DUBRU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THIERRY","family":"DEONNA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05316.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.7.8.523"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1469-8749.1977.tb07969.x","article-title":"Verbal auditory agnosia in children","volume":"19","author":"Rapin I","year":"1977","journal-title":"Dev Med Child Neurol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530280034019"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(94)90108-2"},{"key":"e_1_2_6_7_2","first-page":"265","volume-title":"[Epileptic syndromes in children and adolescents]","author":"Tassinari CA","year":"2002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199107010-00005"},{"key":"e_1_2_6_9_2","volume-title":"Epilepsy in Children","author":"Aicardi J","year":"1986"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(00)00127-3"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2010.06.011"},{"key":"e_1_2_6_12_2","first-page":"299","article-title":"[Electroclinical and developmental aspects of epilepsy in the aphasia\u2010epilepsy syndrome]","volume":"40","author":"Dulac O","year":"1983","journal-title":"Arch Fr Pediatr"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2001.tb00197.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1990.tb05517.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00407-7"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00215.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000167193.53817.0f"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02224.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1981.tb04137.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307389701200804"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000137015.04054.2C"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380311"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.11.043"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2000.tb00057.x"},{"key":"e_1_2_6_25_2","first-page":"215","article-title":"[Utilization of logical formalisms in the examination of aphasic children]","volume":"82","author":"Lowenthal F","year":"1982","journal-title":"Acta Neurol Belg"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199508000-00022"}],"container-title":["Developmental Medicine &amp; 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