{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T17:54:07Z","timestamp":1789408447344,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T00:00:00Z","timestamp":1354579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p><jats:bold>Aim\u2002<\/jats:bold> Having previously shown that comorbidity is a major determinant of neurological sequelae in hypoglycaemia, our aim was to describe the neuroimaging patterns of brain damage in different hypoglycaemic situations and to elucidate the factors that determine lesion topography.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> We reviewed 50 patients (31 females, 19 males) with symptomatic hypoglycaemia (&lt;2.8mmol\/L) occurring between 1\u2003day and 5\u2003years of age (median 4d) who had undergone magnetic resonance imaging (MRI; at least axial T2\u2010weighted, sagittal T1\u2010weighted, and coronal fluid\u2010attenuated inversion recovery [FLAIR]\u2010weighted imaging). MRI was performed during the follow\u2010up examination at least 1\u2003month after the occurrence of symptomatic hypoglycaemia, i.e. between 1\u2003month and 5\u2003years of age (median 3mo). Hypoglycaemia resulted from three inborn errors of metabolism: congenital hyperinsulinism (33 patients), fatty acid \u03b2\u2010oxidation disorders (13 patients), or glycogen storage disease type I (four patients). We selected the patients with clear MRI abnormalities and analysed their topography according to aetiology and age at occurrence of the lesion.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The topography of the brain lesions depended on age: from the neonatal period to 6\u2003months of age, lesions predominantly involved the posterior white matter; between 6 and 22\u2003months the basal ganglia, and after 22\u2003months the parietotemporal cortex (<jats:italic>p<\/jats:italic>=0.04).<\/jats:p><jats:p><jats:bold>Interpretation\u2002<\/jats:bold> The relationship between brain lesions and age could reflect the maturation sequence of the brain.<\/jats:p>","DOI":"10.1111\/dmcn.12045","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T18:40:15Z","timestamp":1354646415000},"page":"162-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Topography of brain damage in metabolic hypoglycaemia is determined by age at which hypoglycaemia occurred"],"prefix":"10.1111","volume":"55","author":[{"given":"SVETLANA","family":"GATAULLINA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PASCALE DE","family":"LONLAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GEORGES","family":"DELLATOLAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VASSILI","family":"VALAYANNAPOULOS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SILVIA","family":"NAPURI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00c9NA","family":"DAMAJ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GUY","family":"TOUATI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CECILA","family":"ALTUZARRA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OLIVIER","family":"DULAC","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NATHALIE","family":"BODDAERT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,4]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"127","article-title":"Neonatal hypoglycemic brain injury \u2013 a common cause of infantile onset remote symptomatic epilepsy","volume":"46","author":"Udani V","year":"2009","journal-title":"Indian Pediatr"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6659.1304"},{"key":"e_1_2_9_4_2","first-page":"523","article-title":"Imaging patterns of neonatal hypoglycemia","volume":"19","author":"Barkovich AJ","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-009-0544-5"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2012.04400.x"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073810371508"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992280504400906"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807300299"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(02)00164-X"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2822"},{"key":"e_1_2_9_12_2","first-page":"1585","article-title":"MR in children with L\u2010carnitine deficiency","volume":"17","author":"Thompson JE","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_9_13_2","first-page":"1222","article-title":"Diffusion\u2010weighted MR imaging in early diagnosis and prognosis of hypoglycemia","volume":"27","author":"Lo L","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.6.1312"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:MEBR.0000043967.78763.5b"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0009922806290610"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.10.012"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.06.003"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-872807"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdmcn.12045","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.12045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dmcn.12045","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.12045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T07:33:05Z","timestamp":1692343985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.12045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,4]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/dmcn.12045"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.12045","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,4]]},"assertion":[{"value":"2012-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}