{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:15:49Z","timestamp":1790615749815,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to examine attention and recognition memory for faces and patterns in Rett syndrome, a severely disabling neurodevelopmental disorder caused by mutations in the X\u2010linked<jats:italic><jats:styled-content style=\"fixed-case\">MECP<\/jats:styled-content>2<\/jats:italic>gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Because Rett syndrome impairs speech and hand use, precluding most neuropsychological testing, the visual paired\u2010comparison paradigm (<jats:styled-content style=\"fixed-case\">VPC<\/jats:styled-content>) was used, together with eye tracking. In the<jats:styled-content style=\"fixed-case\">VPC<\/jats:styled-content>, two identical stimuli are presented for familiarization. On test, the familiar stimulus and a new one are paired, and recognition inferred from preferential looking to the novel target. Attention is measured by looking time, gaze dispersion, and number\/length of fixations. Twenty\u2010seven female patients with Rett syndrome (mean age 10y 6mo; SD 6y 8mo, age range 2\u201322y) from the Rett clinic at a children's hospital were assessed in this study, along with 30 age\u2010 and sex\u2010matched typically developing participants (outpatients from the same hospital).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although patients with Rett syndrome showed recognition of both faces and patterns, with novelty scores greater than chance (50%), their performance was significantly poorer than that of the typically developing comparison group. Their attention to both was less mature and marked by a more narrowly focused gaze, with fewer and longer fixations. When inspecting faces, attention to the eyes was similar in both groups; however, patients with Rett syndrome tended to ignore the nose and mouth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This is one of the first studies to characterize attention and memory in individuals with<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ett syndrome. Visually based techniques, such as the<jats:styled-content style=\"fixed-case\">VPC<\/jats:styled-content>, open a new avenue for quantifying the cognitive phenotype associated with this syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12085","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:57:32Z","timestamp":1363222652000},"page":"364-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Rett syndrome: an eye\u2010tracking study of attention and recognition memory"],"prefix":"10.1111","volume":"55","author":[{"given":"Susan A","family":"Rose","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kennedy Center Albert Einstein College of Medicine\/Children's Hospital at Montefiore Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Djukic","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kennedy Center Albert Einstein College of Medicine\/Children's Hospital at Montefiore Bronx NY"},{"name":"Rett Syndrome Center Montefiore Medical Center Albert Einstein College of Medicine\/Children's Hospital at Montefiore Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery J","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kennedy Center Albert Einstein College of Medicine\/Children's Hospital at Montefiore Bronx NY"},{"name":"Department of Social Sciences Queensborough Community College City University of New York Bayside, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith F","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kennedy Center Albert Einstein College of Medicine\/Children's Hospital at Montefiore Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Fishman","sequence":"additional","affiliation":[{"name":"Rett Syndrome Center Montefiore Medical Center Albert Einstein College of Medicine\/Children's Hospital at Montefiore Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Valicenti\u2010Mcdermott","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kennedy Center Albert Einstein College of Medicine\/Children's Hospital at Montefiore Bronx NY"},{"name":"Rett Syndrome Center Montefiore Medical Center Albert Einstein College of Medicine\/Children's Hospital at Montefiore Bronx NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"723","article-title":"[On an unusual brain atrophy syndrome in hyperammonemia in childhood] (In German)","volume":"116","author":"Rett A","year":"1966","journal-title":"Wien Med Wochenschr"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.10.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22124"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2004.10.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2623-05.2006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138389"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.05.006"},{"key":"e_1_2_8_10_1","unstructured":"JF Fagan PA Shepherd 1987 Infantest Corp Cleveland OH"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.37.1.135"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intell.2009.02.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intell.2011.03.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intell.2006.07.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1996.tb15083.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2011.01404.x"},{"key":"e_1_2_8_17_1","unstructured":"SS Sparrow DV Cicchetti DA Balla 2005 NCS Pearson Inc. 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