{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:53Z","timestamp":1772160113176,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,9]],"date-time":"2013-03-09T00:00:00Z","timestamp":1362787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Difficult\u2010to\u2010treat epilepsies and attention\u2010deficit\u2013hyperactivity disorder (\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      ) often co\u2010occur. Because of concerns about the use of stimulants in children with this comorbidity, the impact of\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      treatment on seizure frequency and severity is not known. This pilot study evaluated the safety and efficacy of methylphenidate in this population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      After a 3\u00a0month period in which antiepileptic drugs were adjusted, 22 patients recruited from a specialist outpatient clinic for severe epilepsy (16 males, six females; mean age 11y 2mo,\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      3y 2mo) received methylphenidate for 3\u00a0months in an open label, non\u2010controlled trial; four with generalized or multifocal (symptomatic\/cryptogenic) epilepsy, one with generalized (idiopathic) epilepsy, 17 with partial (symptomatic\/cryptogenic) epilepsy; five with partial seizures only, 17 with primarily or secondarily generalized seizures). Epilepsy,\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      symptoms, and side effects were assessed using the Swanson, Nolan, and Pelham Questionnaire, the Child Behavior Checklist, the Hague Seizure Severity Scale, and the Side Effects Rating Scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Methylphenidate significantly improved\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      . After 3\u00a0months of treatment, 73% of patients no longer had clinically significant symptoms. Methylphenidate also reduced seizure severity (9\u2010point median decrease on the Hague Seizure Severity Scale). Seizure frequency increased in four out of 22 patients, but only one patient withdrew from the study for this reason. Most patients experienced no major side effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>\n                      These data are among the first showing that low doses of methylphenidate are safe and effective to treat\n                      <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\n                      symptoms in patients with difficult\u2010to\u2010treat epilepsies. Randomized controlled trials are needed to replicate the findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.12121","type":"journal-article","created":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T18:50:16Z","timestamp":1363114216000},"page":"654-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["The impact of methylphenidate on seizure frequency and severity in children with attention\u2010deficit\u2013hyperactivity disorder and difficult\u2010to\u2010treat epilepsies"],"prefix":"10.1111","volume":"55","author":[{"given":"Kleber","family":"Santos","sequence":"first","affiliation":[{"name":"Severe Epilepsies Outpatient Clinic Neurology Service Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Palmini","sequence":"additional","affiliation":[{"name":"Severe Epilepsies Outpatient Clinic Neurology Service Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) Porto Alegre Brazil"},{"name":"Porto Alegre Epilepsy Surgery Program Hospital S\u00e3o Lucas da PUCRS Porto Alegre Brazil"},{"name":"Department of Internal Medicine Faculty of Medicine PUCRS Porto Alegre Brazil"},{"name":"The Brain Institute (InsCer) PUCRS Porto Alegre Brazil Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L","family":"Radziuk","sequence":"additional","affiliation":[{"name":"Severe Epilepsies Outpatient Clinic Neurology Service Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana","family":"Rotert","sequence":"additional","affiliation":[{"name":"Severe Epilepsies Outpatient Clinic Neurology Service Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Bastos","sequence":"additional","affiliation":[{"name":"Severe Epilepsies Outpatient Clinic Neurology Service Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Booij","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sainte\u2010Justine Montreal Canada"},{"name":"Department of Psychiatry University of Montreal Montreal Quebec Canada"},{"name":"Department of Psychiatry McGill University Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brisa S","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laboratory of Calcium Binding Proteins in the Central Nervous System Department of Biochemistry Federal University of Rio Grande do Sul Porto Alegre Brazil"},{"name":"Post\u2010graduate Program in Biological Sciences: Biochemistry Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Children with epilepsy as adults: outcome after 30\u00a0years of follow\u2010up","volume":"368","author":"Sillanpaa M","year":"1990","journal-title":"Acta Paediatr Suppl"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2003.tb00398.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.25002.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01390.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2217\/fnl.09.32"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01028.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2011.01.019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1542\/peds.54.5.658b","article-title":"Convulsions and ritalin?","volume":"54","author":"Chamberlain RW","year":"1974","journal-title":"Pediatrics"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.02.022"},{"key":"e_1_2_8_11_1","first-page":"1081","article-title":"Methylphenidate in children with seizures and attention\u2010deficit disorder","volume":"143","author":"Feldman H","year":"1989","journal-title":"Am J Dis Child"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70258-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738030180020601"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.02.029"},{"key":"e_1_2_8_15_1","volume-title":"Task Force on D\u2010I. 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