{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:47:10Z","timestamp":1790192830075,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to describe the magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) findings and the neurological and neuropsychological outcomes in paediatric, diarrhoea\u2010associated haemolytic\u2013uraemic syndrome (D+<jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>) with central nervous system impairment treated with eculizumab, a monoclonal antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The 14\u2010month single\u2010centre prospective study included seven children (three males, four females; age range 16mo\u20137y 8mo; median age 3y 7mo) with typical D+<jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content> and acute neurological impairment. In the acute phase of the disease, neurological assessment and brain magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>), including measurement of the apparent diffusion coefficient (<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>), were performed, and neuropsychological evaluation and brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> were also carried out 6\u00a0months after disease onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the acute phase, basal ganglia and white matter abnormalities with <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> restriction were a common and reversible <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> finding. In all the surviving patients (5\/7), follow\u2010up <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> after 6\u00a0months was normal, indicating reversible lesions. Clinical and neuropsychological evaluations after 6\u00a0months were also normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This specific brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> pattern consisting of an <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> decrease in basal ganglia and white matter without major <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2\/fluid\u2010attenuated inversion recovery (<jats:styled-content style=\"fixed-case\">FLAIR<\/jats:styled-content>) injury may be a key finding in the acute phase of the disease in favour of a vasculitis hypothesis. These reversible lesions were associated with a good neurological outcome. These results call for further evaluation of the potential role of eculizumab in the choice of treatment for severe D+<jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>, particularly in the case of early neurological signs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12161","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T09:15:01Z","timestamp":1368177301000},"page":"758-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Brain magnetic resonance imaging pattern and outcome in children with haemolytic\u2010uraemic syndrome and neurological impairment treated with eculizumab"],"prefix":"10.1111","volume":"55","author":[{"given":"Cyril","family":"Gitiaux","sequence":"first","affiliation":[{"name":"Pediatric Neurology Department Necker\u2010Enfants Malades Hospital APHP Paris 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