{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T18:17:12Z","timestamp":1774894632052,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Autism spectrum disorders (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s) are a group of heterogeneous neurodevelopmental disorders that show impaired communication and socialization, restricted interests, and stereotypical behavioral patterns. Recent advances in molecular medicine and high throughput screenings, such as array comparative genomic hybridization (<jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content>) and exome and whole genome sequencing, have revealed both novel insights and new questions about the nature of this spectrum of disorders. What has emerged is a better understanding about the genetic architecture of various genetic subtypes of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and correlations of genetic mutations with specific autism subtypes. Based on this new information, we outline a strategy for advancing diagnosis, prognosis, and counseling for patients and families.<\/jats:p>","DOI":"10.1111\/dmcn.12278","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:26:18Z","timestamp":1381541178000},"page":"12-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["The genetic landscape of autism spectrum disorders"],"prefix":"10.1111","volume":"56","author":[{"given":"Rasim O","family":"Rosti","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Pediatrics Howard Hughes Medical Institute University of California San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelrahim A","family":"Sadek","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Department of Pediatrics Faculty of Medicine Sohag University Sohag 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