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Gallbladder function in 25 females (mean age 16y 5mo, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 20y 7mo, range 3y 5mo\u201347y 10mo) with Rett syndrome (<jats:styled-content style=\"fixed-case\">RTT<\/jats:styled-content>) was evaluated with clinical assessment and ultrasound of the gallbladder. The Delphi technique was used to develop assessment and treatment recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence rate for cholelithiasis and\/or cholecystectomy was 2.3 (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.1\u20134.2) and 1.8 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0\u20133.0) per 1000 person\u2010years in the Australian and International Databases respectively. The mean contractility index of the gallbladder for the clinical sample was 46.5% (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 38.3%), smaller than for healthy individuals but similar to children with Down syndrome, despite no clinical symptoms. After excluding gastroesophageal reflux, gallbladder disease should be considered as a cause of abdominal pain in <jats:styled-content style=\"fixed-case\">RTT<\/jats:styled-content> and cholecystectomy recommended if symptomatic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Gallbladder disease is relatively common in <jats:styled-content style=\"fixed-case\">RTT<\/jats:styled-content> and should be considered in the differential diagnosis of abdominal pain in <jats:styled-content style=\"fixed-case\">RTT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12358","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T11:09:59Z","timestamp":1392635399000},"page":"756-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prevalence, clinical investigation, and management of gallbladder disease in Rett syndrome"],"prefix":"10.1111","volume":"56","author":[{"given":"Michael","family":"Freilinger","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Lanator","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Vergesslich\u2010Rothschild","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf\u2010Dietrich","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Anderson","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research Centre for Child Health Research The University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingsley","family":"Wong","sequence":"additional","affiliation":[{"name":"Telethon Institute for Child Health Research Centre for Child Health Research The University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Baikie","sequence":"additional","affiliation":[{"name":"Department of Developmental Medicine Royal Children's Hospital Murdoch Childrens Research Institute Melbourne Vic Australia"},{"name":"Department of Paediatrics University of Melbourne Melbourne Vic. 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