{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:44:22Z","timestamp":1776883462318,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:00:00Z","timestamp":1391558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Hemimegalencephaly (<jats:styled-content style=\"fixed-case\">HME<\/jats:styled-content>) is a rare congenital malformation of cortical development, usually associated with developmental delay and severe epilepsy. This condition has rarely been reported in adults. The aim of this study was to examine and compare neurological findings in adult patients with <jats:styled-content style=\"fixed-case\">HME<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively examined adult patients with <jats:styled-content style=\"fixed-case\">HME<\/jats:styled-content> by evaluating the presence of neurocutaneous disorders, current cognitive development, seizure control, and documentation of therapies for seizure management and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients were included in the study (three males, two females; mean age 23y 9mo [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 6y 1mo], range 18\u201334y). Four patients had <jats:styled-content style=\"fixed-case\">HME<\/jats:styled-content> that was associated with neurocutaneous syndromes and the remaining patient had isolated <jats:styled-content style=\"fixed-case\">HME<\/jats:styled-content>. Two patients required surgical treatment for seizures in childhood. One patient had no intellectual disability, while one had mild, and three severe intellectual disability. All patients presented motor deficits ranging from mild hemiparesis in two patients to non\u2010ambulation in one patient. Patients in whom seizure onset occurred after the 7\u00a0years of age had better seizure control and psychomotor development in adulthood than patients in whom seizure onset occurred in the first year of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>In our small sample of adults with <jats:styled-content style=\"fixed-case\">HME<\/jats:styled-content>, age at seizure onset, cognitive disability, and seizure control were found to be associated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12390","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T12:21:32Z","timestamp":1391602892000},"page":"905-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hemimegalencephaly: what happens when children get older?"],"prefix":"10.1111","volume":"56","author":[{"given":"Nicky","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Neurology Epilepsy Genetics Program Toronto Western Hospital Krembil Neuroscience Centre University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felippe","family":"Borlot","sequence":"additional","affiliation":[{"name":"Division of Neurology Epilepsy Genetics Program Toronto Western Hospital Krembil Neuroscience Centre University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anfal","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Neurology Epilepsy Genetics Program Toronto Western Hospital Krembil Neuroscience Centre University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Krings","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology Department of Medical Imaging Toronto Western Hospital University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle M","family":"Andrade","sequence":"additional","affiliation":[{"name":"Division of Neurology Epilepsy Genetics Program Toronto Western Hospital Krembil Neuroscience Centre University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-9752(07)87010-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-006-0149-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700512"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2007.10.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31024"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00838167"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(97)00090-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2329"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2005.tb00518.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2006.00818.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2009000300041"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.01013.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2010.09.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1745.40586"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)35040-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826c1b55"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(01)00318-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000055953"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb05557.x"},{"key":"e_1_2_7_21_1","first-page":"1076","article-title":"Hemimegalencephaly and intractable epilepsy treated with embolic hemispherectomy","volume":"16","author":"Mathis JM","year":"1995","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2011.04136.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.05.030"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdmcn.12390","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.12390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:07:52Z","timestamp":1695510472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.12390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,5]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/dmcn.12390"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.12390","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,5]]},"assertion":[{"value":"2013-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}