{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:51:46Z","timestamp":1789944706388,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the association between cytochrome P450 2D6 (<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6) phenotypes in paediatric patients with autistic spectrum disorders (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) treated with risperidone, adverse drug reactions (<jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s), and drug efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>An observational cohort study of 40 children (34 males, six females; median age 7y range 3\u201318y) with autistic disorder, pervasive developmental disorder not otherwise specified, or Asperger syndrome diagnosed using the Autism Diagnostic Interview\u2010Revised and treated with risperidone for at least 3\u00a0months. Charts were reviewed for demographic and clinical information, response to treatment was assessed by parents and the treating neurologist on a three\u2010point scale, and information about <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s was collected. Trough plasma levels of risperidone and its metabolites were determined and <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6 genotyping was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six patients responded to therapy and 11 patients exhibited <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s. <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6 genotyping showed two patients to be poor metabolizers, two ultra\u2010rapid metabolizers, seven intermediate metabolizers, and 29 extensive metabolizers. Both ultra\u2010rapid metabolizer patients were non\u2010responders and had no <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s. In contrast, both poor metabolizer patients were responders but experienced <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s. No correlation was found between risperidone dosage and either risperidone or drug metabolite plasma levels. There was no difference in risperidone or metabolite plasma levels when comparing responders to non\u2010responders, or when comparing patients with or without <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>In patients with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> treated with risperidone, a <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>2D6 phenotype may be associated with response to treatment and development of <jats:styled-content style=\"fixed-case\">ADR<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12470","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T08:25:09Z","timestamp":1400142309000},"page":"990-994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["<scp>CYP<\/scp>2D6 genotyping in paediatric patients with autism treated with risperidone: a preliminary cohort study"],"prefix":"10.1111","volume":"56","author":[{"given":"Ilan","family":"Youngster","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Unit Assaf Harofeh Medical Center Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditza A","family":"Zachor","sequence":"additional","affiliation":[{"name":"The Autism Center Assaf Harofeh Medical Center Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia V","family":"Gabis","sequence":"additional","affiliation":[{"name":"Child Developmental Center Safra Children's Hospital Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina","family":"Bar\u2010Chaim","sequence":"additional","affiliation":[{"name":"Pharmacogenetics Laboratory Assaf Harofeh Medical Center Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Benveniste\u2010Levkovitz","sequence":"additional","affiliation":[{"name":"Pharmacogenetics Laboratory Assaf Harofeh Medical Center Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malka","family":"Britzi","sequence":"additional","affiliation":[{"name":"The National Residue Control Laboratory Ministry of Agriculture Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Soback","sequence":"additional","affiliation":[{"name":"The National Residue Control Laboratory Ministry of Agriculture Hebrew University Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Ziv\u2010Baran","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine School of Public Health Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matitiahu","family":"Berkovitch","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Unit Assaf Harofeh Medical Center Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.6.1142"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-0264-F"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0683"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-006-0234-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2010.0145"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0984"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500285"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/16.9.581"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0103"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/159402"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2010.91"},{"key":"e_1_2_7_13_1","first-page":"1","article-title":"Paediatric pharmacogenomics: an overview","volume":"98","author":"Hawcutt DB","year":"2012","journal-title":"Arch Dis Child"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2012.45"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1025"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2008.05.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.09.15"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2009.63"},{"key":"e_1_2_7_19_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorder","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_7_20_1","volume-title":"Autism Diagnostic Interview\u2010Revised (ADI\u2010R)","author":"Le Couteur A","year":"2003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02408436"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.07.026"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)00323-6"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)90148-4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.4.542"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3182126d83"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181a289e0"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdmcn.12470","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.12470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:11:25Z","timestamp":1695489085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.12470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,15]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/dmcn.12470"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.12470","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,15]]},"assertion":[{"value":"2014-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}