{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:11:30Z","timestamp":1770221490861,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T00:00:00Z","timestamp":1399680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Head thrusts are well documented in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>oubert syndrome and ocular motor apraxia. We provide a detailed clinical characterization of head titubation in 13 young children with <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>oubert syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Detailed characterization of head titubation was assessed by targeted clinical evaluation and\/or analysis of videos.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 12 of 13 children (eight males, five females; median age 6y, range 2mo\u201315y) head titubation was first recognized in the first 2\u00a0months of age and decreased in severity until spontaneous resolution. In all children, the head titubation was horizontal, high frequency (~3Hz), had small amplitude (5\u201310\u00b0), was never present during sleep, and did not interfere with the neurodevelopment during infancy. In the majority of children, emotion, anxiety, and tiredness were worsening factors for head titubation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Head titubation is a benign, early presentation of <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>oubert syndrome. Head titubation in hypotonic infants should prompt a careful search for <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>oubert syndrome. Awareness of its occurrence in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>oubert syndrome may avoid unnecessary investigations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12489","type":"journal-article","created":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T09:38:59Z","timestamp":1399714739000},"page":"1016-1020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Horizontal head titubation in infants with <scp>J<\/scp>oubert syndrome: a new finding"],"prefix":"10.1111","volume":"56","author":[{"given":"Andrea","family":"Poretti","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology University Children's Hospital Zurich Switzerland"},{"name":"Section of Pediatric Neuroradiology Division of Pediatric Radiology Russell H Morgan Department of Radiology and Radiological Science The Johns Hopkins University School of Medicine Baltimore MD 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