{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:22:18Z","timestamp":1791134538116,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000276","name":"Department of Health","doi-asserted-by":"publisher","award":["039\/0031"],"award-info":[{"award-number":["039\/0031"]}],"id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate whether children in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ngland with narcolepsy who received the <jats:styled-content style=\"fixed-case\">ASO<\/jats:styled-content>3 adjuvanted pandemic <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>1 2009 influenza vaccine (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>andemrix) differed clinically from unvaccinated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective review was conducted in children with narcolepsy diagnosed by sleep centres and paediatric neurologists in 16 <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nglish hospitals. The inclusion criteria were patient age 4 to 18\u00a0years, onset of narcolepsy after January 2008, and diagnosis by the time of the key data\u2010gathering visit in 2011. Clinical data came from hospital notes and general practitioner questionnaires. An expert panel validated the diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010five patients with narcolepsy were identified (43 males, 32 females; mean age at onset 10y 4mo, range 3\u201318y). Of these patients, 11 received the Pandemrix vaccine before narcolepsy onset. On first presentation, there were more frequent reports of cataplexy, among other features, in vaccinated than in unvaccinated patients (82% vs 55%), but only excessive weight gain (55% vs 20%) was significantly more frequent (<jats:italic>p<\/jats:italic>=0.03). Facial hypotonia (<jats:italic>p<\/jats:italic>=0.03) and tongue protrusion (<jats:italic>p<\/jats:italic>=0.01) were eventually seen more frequently in vaccinated children. When considering patients diagnosed within a year of onset, vaccinated children were not diagnosed more rapidly than unvaccinated children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Some symptoms and signs of narcolepsy were more frequently reported in <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>andemrix\u2013vaccinated patients. There was no evidence of the more rapid diagnosis in vaccinated patients that has been reported in <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>inland and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>weden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12522","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T05:31:34Z","timestamp":1404970294000},"page":"1117-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Clinical features of narcolepsy in children vaccinated with <scp>AS<\/scp>03 adjuvanted pandemic <scp>A<\/scp>\/<scp>H<\/scp>1<scp>N<\/scp>1 2009 influenza vaccine in <scp>E<\/scp>ngland"],"prefix":"10.1111","volume":"56","author":[{"given":"Anne Marie","family":"Winstone","sequence":"first","affiliation":[{"name":"PIND Research Group Addenbrooke's Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Stellitano","sequence":"additional","affiliation":[{"name":"PIND Research Group Addenbrooke's Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Verity","sequence":"additional","affiliation":[{"name":"PIND Research Group Addenbrooke's Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Andrews","sequence":"additional","affiliation":[{"name":"Statistics, Modelling and Economics Department Health Protection Directorate Public Health England London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Miller","sequence":"additional","affiliation":[{"name":"Immunisation, Hepatitis and Blood Safety Department Health Protection Directorate Public Health England London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Stowe","sequence":"additional","affiliation":[{"name":"Immunisation, Hepatitis and Blood Safety Department Health Protection Directorate Public Health England London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Shneerson","sequence":"additional","affiliation":[{"name":"Respiratory Support and Sleep Centre Papworth Hospital Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033536"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033723"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828ab26f"},{"key":"e_1_2_8_5_1","first-page":"193","volume-title":"Immunisation Against Infectious Disease","author":"Department of Health","year":"2006"},{"key":"e_1_2_8_6_1","unstructured":"Chief Medical Officer's Update 2009 Department of Health"},{"key":"e_1_2_8_7_1","unstructured":"Department of Health. (2009)Extension of the Swine Flu Vaccination Programme.Department of Health.http:\/\/webarchive.nationalarchives.gov.uk\/+\/www.dh.gov.uk\/en\/Publichealth\/Flu\/Swineflu\/InformationandGuidance\/Vaccinationprogramme\/DH_108850(accessed 9 October 2013)."},{"key":"e_1_2_8_8_1","unstructured":"Department of Health. (2010)Pandemic H1N1 (Swine) Influenza Vaccine Uptake Amongst Patient Groups in Primary Care in England 2009\/10 DH\/HPA.www.dh.gov.uk\/prod_consum_dh\/groups\/dh_digitalassets\/@dh\/@en\/@ps\/documents\/digitalasset\/dh_121014.pdf(accessed 9 October 2013)."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f794"},{"key":"e_1_2_8_10_1","unstructured":"Hospital Episode Statistics.National Health Service (NHS).www.hesonline.nhs.uk\/Ease\/servlet\/ContentServer?siteID=1937(accessed 9 August 2013)."},{"key":"e_1_2_8_11_1","volume-title":"International Statistical Classification of Diseases and Related Problems, 10th Revision","author":"World Health Organization","year":"2010"},{"key":"e_1_2_8_12_1","volume-title":"International Classification of Sleep Disorders: Diagnostic and Coding Manual","author":"American Academy of Sleep Medicine","year":"2005"},{"key":"e_1_2_8_13_1","unstructured":"National Narcolepsy Study Steering Committee.Investigation of an Increase in the Incidence of Narcolepsy in Children and Adolescents in 2009 and 2010.http:\/\/healthupdate.gov.ie\/wpcontent\/uploads\/2012\/04\/Final_Report_of_National_Narcolepsy_Study_Steering_Committee-latest1.pdf(accessed 6 August 2012)."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.03.020"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt187"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.10.030"},{"key":"e_1_2_8_17_1","volume-title":"Narcolepsy in Association with Pandemic Influenza Vaccination: A Multi\u2010Country European Epidemiological Investigation","author":"European Centre for Disease Prevention and Control","year":"2012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068402"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22587"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91977-6"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1212\/WNL.50.2_Suppl_1.S16","article-title":"Genetic and familial aspects of narcolepsy","volume":"50","author":"Mignot E","journal-title":"Neurology"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.11.2137"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr244"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.12.014"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1128"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05582-8"},{"key":"e_1_2_8_27_1","first-page":"1907","volume-title":"Neuropsychopharmacology: The Fifth Generation of Progress","author":"Mignot E","year":"2002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.10.1553"},{"key":"e_1_2_8_29_1","first-page":"1","article-title":"CD4+ T cell autoimmunity to hypocretin\/orexin and cross\u2010reactivity to a 2009 H1N1 influenza A epitope in narcolepsy","volume":"5","author":"Herr\u00e1n\u2010Arita AK","year":"2013","journal-title":"Sci Transl Med"}],"container-title":["Developmental Medicine &amp; Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fdmcn.12522","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.12522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/dmcn.12522","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/dmcn.12522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:10:27Z","timestamp":1696367427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/dmcn.12522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,10]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/dmcn.12522"],"URL":"https:\/\/doi.org\/10.1111\/dmcn.12522","archive":["Portico"],"relation":{},"ISSN":["0012-1622","1469-8749"],"issn-type":[{"value":"0012-1622","type":"print"},{"value":"1469-8749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,10]]},"assertion":[{"value":"2014-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}