{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:30:31Z","timestamp":1787063431885,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to examine whether vigabatrin treatment had caused visual field defects (\n                      <jats:styled-content style=\"fixed-case\">VFD<\/jats:styled-content>\n                      s) in children of school age who had received the drug in infancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In total, 35 children (14 males, 21 females; median age 11y,\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      3.4y, range 8\u201323y) were examined by static Humphrey perimetry, Goldmann kinetic perimetry, or Octopus perimetry. The aetiologies of infantile spasms identified were tuberous sclerosis (\n                      <jats:italic>n<\/jats:italic>\n                      =10), other symptomatic causes (\n                      <jats:italic>n<\/jats:italic>\n                      =3), or cryptogenic (\n                      <jats:italic>n<\/jats:italic>\n                      =22).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Typical vigabatrin\u2010attributed\n                      <jats:styled-content style=\"fixed-case\">VFD<\/jats:styled-content>\n                      s were found in 11 out of 32 (34%) children: in one out of 11 children (9%) who received vigabatrin for &lt;1\u00a0year (group 1), in three out of 10 children (30%) who received vigabatrin for 12 to 24\u00a0months (group 2), and in seven out of 11 children (63%) who received vigabatrin treatment for longer than 2\u00a0years (group 3).\n                      <jats:styled-content style=\"fixed-case\">VFD<\/jats:styled-content>\n                      s were mild in five and severe in six children. Patients with tuberous sclerosis were at higher risk of\n                      <jats:styled-content style=\"fixed-case\">VFD<\/jats:styled-content>\n                      s (six out of 10 children). The mean cumulative doses of vigabatrin were 140.5, 758.8, and 2712g in group 1, 2, and 3, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">VFD<\/jats:styled-content>\n                      s were found in 34% of the cohort of children in this study. The rate of\n                      <jats:styled-content style=\"fixed-case\">VFD<\/jats:styled-content>\n                      increased from 9% to 63% as duration of treatment increased. The results of this study showed that the risk\u2013benefit ratio should always be considered when using vigabatrin.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.12573","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T01:00:51Z","timestamp":1408669251000},"page":"60-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Does vigabatrin treatment for infantile spasms cause visual field defects? 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