{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:13:06Z","timestamp":1785255186806,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T00:00:00Z","timestamp":1408665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study was to characterize seizures and epilepsy related to hypoglycaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We analyzed the files of 170 consecutive patients referred for hypoglycaemia (onset 1h to 4y) caused by inborn errors of metabolism (glycogen storage disease type I, fatty acid <jats:italic>\u03b2<\/jats:italic>\u2010oxidation disorders, and hyperinsulinism).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety patients (42 males and 48 females; 38 neonates and 52 infants\/children) had brief hypoglycaemic seizures (68%) or status epilepticus (32%). Status epilepticus occurred earlier (mean 1.4d) than brief neonatal seizures (4.3d, <jats:italic>p<\/jats:italic>=0.02). Recurrent status epilepticus followed initial status epilepticus and was often triggered by fever. Epilepsy developed in 21 patients. In 18 patients, epilepsy followed hypoglycaemic status epilepticus and began with shorter delay when associated with grey matter lesions (1.9mo, standard error of the mean [<jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>] 1mo) than with white matter damage (3.3y [<jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content> 1y], <jats:italic>p<\/jats:italic>=0.003). Three patients with hyperinsulinism developed idiopathic epilepsy following brief neonatal seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Brief neonatal hyperinsulinaemic hypoglycaemic seizures have characteristics of idiopathic neonatal seizures. Neonatal status epilepticus should be prevented by the systematic measurement of glucose blood level. Recurrent seizures never consist of status epilepticus when following brief initial seizures. Epilepsy is symptomatic of brain damage with shorter delay in the case of grey rather than white matter lesions, except in a few idiopathic cases in which epilepsy and hyperinsulinism may share a common genetic background.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12574","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T04:39:31Z","timestamp":1408682371000},"page":"194-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Seizures and epilepsy in hypoglycaemia caused by inborn errors of metabolism"],"prefix":"10.1111","volume":"57","author":[{"given":"Svetlana","family":"Gataullina","sequence":"first","affiliation":[{"name":"Inserm U1129 Paris France"},{"name":"CEA Gif\u2010sur\u2010Yvette France"},{"name":"Paris Descartes University Paris 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