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Parametric maps were generated for fractional anisotropy, mean, radial, and axial diffusivity. CC and <jats:styled-content style=\"fixed-case\">CST<\/jats:styled-content> were segmented by <jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>\u2010based tractography. Multiple regression models were used to examine the association of <jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content> measures with Bayley\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> Mental (<jats:styled-content style=\"fixed-case\">MDI<\/jats:styled-content>) and Psychomotor Developmental Index (<jats:styled-content style=\"fixed-case\">PDI<\/jats:styled-content>) at 15 months and 21\u00a0months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two infants (males <jats:italic>n<\/jats:italic>=32, females <jats:italic>n<\/jats:italic>=20) underwent <jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content> at median age of 8\u00a0days. Two were excluded because of poor magnetic resonance imaging quality. Outcomes were assessed in 42\/50 (84%) children at 15\u00a0months and 35\/50 (70%) at 21\u00a0months. Lower CC and <jats:styled-content style=\"fixed-case\">CST<\/jats:styled-content> fractional anisotropy were associated with lower <jats:styled-content style=\"fixed-case\">MDI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PDI<\/jats:styled-content> respectively, even after controlling for gestational age, birth weight, sex, and socio\u2010economic status. There was also a direct relationship between CC axial diffusivity and <jats:styled-content style=\"fixed-case\">MDI<\/jats:styled-content>, while <jats:styled-content style=\"fixed-case\">CST<\/jats:styled-content> radial diffusivity was inversely related to <jats:styled-content style=\"fixed-case\">PDI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>In encephalopathic newborn infants, impaired microstructural organization of the CC and <jats:styled-content style=\"fixed-case\">CST<\/jats:styled-content> predicts poorer cognitive and motor performance respectively. Tractography provides a reliable method for early assessment of perinatal brain injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/dmcn.12646","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T05:39:49Z","timestamp":1418189989000},"page":"441-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["White matter tract integrity and developmental outcome in newborn infants with hypoxic\u2010ischemic encephalopathy treated with hypothermia"],"prefix":"10.1111","volume":"57","author":[{"given":"An N","family":"Massaro","sequence":"first","affiliation":[{"name":"Division of Neonatology Children's National Medical Center Washington DC USA"},{"name":"Department of Pediatrics The George Washington University School of Medicine Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iordanis","family":"Evangelou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The George Washington University School of Medicine Washington DC USA"},{"name":"Department of Diagnostic Imaging and Radiology Children's National Medical Center Washington DC USA"},{"name":"Department of Radiology The George Washington University School of Medicine Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Fatemi","sequence":"additional","affiliation":[{"name":"Kennedy Krieger Institute Johns Hopkins School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Vezina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The George Washington University School of Medicine Washington DC USA"},{"name":"Department of Diagnostic Imaging and Radiology Children's National Medical Center Washington DC USA"},{"name":"Department of Radiology The George Washington University School of Medicine Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Mccarter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The George Washington University School of Medicine Washington DC USA"},{"name":"Department of Biostatistics &amp; Informatics Children's National Medical Center Washington DC USA"},{"name":"Department of Epidemiology &amp; Biostatistics The George Washington University School of Medicine Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny","family":"Glass","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The George Washington University School of Medicine Washington DC USA"},{"name":"Division of Psychology and Behavioral Health Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Limperopoulos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The George Washington University School of Medicine Washington DC USA"},{"name":"Department of Diagnostic Imaging and Radiology Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738010160110201"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.08.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.03.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.12.026"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-301524"},{"key":"e_1_2_8_8_1","first-page":"143","article-title":"Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems","volume":"19","author":"Barkovich AJ","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-964869"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1805"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0545"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.40"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20410"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2393041523"},{"key":"e_1_2_8_15_1","first-page":"2372","article-title":"Optimized methodology for neonatal diffusion tensor imaging processing and study\u2010specific template construction","volume":"36","author":"Evangelou I","year":"2014","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0086"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.178.1.1780003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.12.030"},{"key":"e_1_2_8_19_1","volume-title":"Manual for the Bayley Scales of Infant Development","author":"Bayley N","year":"1969"},{"key":"e_1_2_8_20_1","volume-title":"Bayley Scales of Infant Development","author":"Bayley N","year":"2006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.6.824"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1202-5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0751"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rct.0000226397.43235.8b"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2816"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1267"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198805000-00003"}],"container-title":["Developmental Medicine &amp; 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