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They can be documented in a host of neurodevelopmental conditions and approached with the recently refined perception\u2013action\u2013cognition\u2013environment (<jats:styled-content style=\"fixed-case\">PACE<\/jats:styled-content>) paradigm, which focuses on the neurodevelopmental processes that underlie learning and adaption to the environment through perception, action, and cognitive processing. Although this paradigm was originally developed in the context of cerebral palsy, it can be applied along developmental trajectories in several neurogenetic conditions, including Down syndrome, fragile X syndrome, Rett syndrome, Angelman syndrome, and Williams syndrome, to name but a few. 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