{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:03Z","timestamp":1787014083486,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to determine the frequency and characteristics of secondary enuresis in children initiated on valproate treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This was a prospective study conducted in children aged 5 to 12\u00a0years with suspected newly diagnosed epilepsy and maintained on valproate for at least 1\u00a0month. Adverse events spontaneously reported by parents were recorded at each follow\u2010up visit. In addition, we specifically asked about enuresis and other side effects known to occur with valproate treatment. We assessed the frequency of enuresis and its association with a number of variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010two children (43 males and 29 females) with a mean age of 8\u00a0years 7\u00a0months (range 5\u201312y) were included in this study. Secondary enuresis developed in 17 (24%) of these children after, on average, 19.8\u00a0days of exposure to valproate. The data obtained from a multivariate analysis indicate that age was the only significant factor in predicting the development of enuresis. Enuresis ceased in all children after discontinuation of valproate use, and in 10 out of 11 children still on the drug.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Secondary enuresis is a common adverse event associated with valproate use in children, which is not usually spontaneously reported and is reversible in most cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dmcn.12737","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T04:04:48Z","timestamp":1427256288000},"page":"737-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Valproate\u2010induced enuresis: a prospective study"],"prefix":"10.1111","volume":"57","author":[{"given":"Wissam R","family":"Yamak","sequence":"first","affiliation":[{"name":"Department of Neurology American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan","family":"Hmaimess","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Saint George Hospital University Medical Center University of Balamand Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamane","family":"Makke","sequence":"additional","affiliation":[{"name":"Department of Neurology American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hotel Dieu de France Hospital Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maher","family":"Arabi","sequence":"additional","affiliation":[{"name":"Department of Neurology Ibn Sina Hospital Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Beydoun","sequence":"additional","affiliation":[{"name":"Department of Neurology American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Nasreddine","sequence":"additional","affiliation":[{"name":"Department of Neurology American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"US Food and Drug Administration. (2009)Depakote Tablets (divalproex sodium) Tablet (Abbott Laboratories). 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