{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:25:10Z","timestamp":1770510310724,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Develop Med Child Neuro"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Subacute sclerosing panencephalitis (<jats:styled-content style=\"fixed-case\">SSPE<\/jats:styled-content>) is a serious, often fatal disease that responds poorly to current treatment modalities. Recently, the ability of mesenchymal stem cells (<jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s) to produce neurotrophic factors and inflammatory molecules has placed them among potential treatment agents for neurological conditions. We report the results of four patients treated with <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">SSPE<\/jats:styled-content>. The patients were followed up clinically, and by periodical laboratory evaluations, magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>), and electroencephalography. One patient deteriorated to stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> of the disease, two patients remained in the same stage, and one died from disease progression and respiratory problems. Neurological findings and electroencephalography scores were consistent with the clinical course of the patient whereas <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> showed new inflammatory lesions in two patients. This is the first report of the application of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SSPE<\/jats:styled-content>. No benefit is demonstrated.<\/jats:p>","DOI":"10.1111\/dmcn.12747","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T13:44:18Z","timestamp":1428327858000},"page":"880-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mesenchymal stem cell application in children with subacute sclerosing panencephalitis"],"prefix":"10.1111","volume":"57","author":[{"given":"Bari\u015f","family":"Ku\u015fkonmaz","sequence":"first","affiliation":[{"name":"Division of Bone Marrow Transplantation Department of Pediatrics Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duygu","family":"U\u00e7kan","sequence":"additional","affiliation":[{"name":"Division of Bone Marrow Transplantation Department of Pediatrics Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"Yalnizo\u011flu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Department of Pediatrics Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mintaze","family":"G\u00fcnel","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation Faculty of Health Science Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kader","family":"Karli O\u011fuz","sequence":"additional","affiliation":[{"name":"Department of Radiology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahadir","family":"Konu\u015fkan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Department of Pediatrics Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Anlar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology Department of Pediatrics Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-0425-7_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000749"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2011.01.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.08.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389701200611"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2005.00565.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/74.7.630"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/80.10.974"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199705000-00005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1278"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S25745"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.02.021"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0528"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042678299"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14017430903556294"}],"container-title":["Developmental Medicine &amp; 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